N-[2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-malonamic acid methyl ester

Base Information

Chemical Name:N-[2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-malonamic acid methyl ester
CAS No.:1386981-58-3
Molecular Formula:C₁₈H₁₅ClF₂N₂O₄
Molecular Weight:396.778
Hs Code.:

Synonyms:N-[2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-malonamic acid methyl ester

Suppliers and Price of N-[2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-malonamic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of N-[2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-malonamic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-malonamic acid methyl ester

There total 2 articles about N-[2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-malonamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.4%

: 37517-81-0
3-chloro-3-oxopropanoic acid methyl ester

: 1386981-57-2
5-amino-4-chloro-2-fluoro-N-(3-fluoro-benzyl)-benzamide

: 1386981-58-3
N-[2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-malonamic acid methyl ester

Guidance literature:: 5-amino-4-chloro-2-fluoro-N-(3-fluoro-benzyl)-benzamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.05h; Cooling with ice;

3-chloro-3-oxopropanoic acid methyl ester; In dichloromethane; for 1.03333h; Cooling with ice;

Reference yield:

: 100-82-3
(3-fluorophenyl)methanamine

: 1386981-58-3
N-[2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-malonamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h

1.2: 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.05 h / Cooling with ice

2.2: 1.03 h / Cooling with ice

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;