2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-amide

Base Information

Chemical Name:2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-amide
CAS No.:1386980-36-4
Molecular Formula:C₂₆H₂₁ClF₂N₆O₄
Molecular Weight:554.94
Hs Code.:

Synonyms:2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-amide

There total 5 articles about 2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.2%

: 1386981-32-3
4-amino-2-morpholinopyrimidine-5-carbaldehyde

: 1386981-58-3
N-[2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-malonamic acid methyl ester

: 1386980-36-4
2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-amide

Guidance literature:: With piperidine; In methanol; at 80 ℃; for 11h; sealed tube;

Reference yield:

: 100-82-3
(3-fluorophenyl)methanamine

: 1386980-36-4
2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h

1.2: 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.05 h / Cooling with ice

2.2: 1.03 h / Cooling with ice

3.1: piperidine / methanol / 11 h / 80 °C / sealed tube

With piperidine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1386981-31-2
(4-amino-2-morpholinopyrimidin-5-yl)methanol

: 1386980-36-4
2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-4-fluoro-5-(3-fluoro-benzylcarbamoyl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 24 h / Inert atmosphere

2: piperidine / methanol / 11 h / 80 °C / sealed tube

With piperidine; manganese(IV) oxide; In methanol; dichloromethane;