[(3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-yl]methanol

Base Information

Chemical Name:[(3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-yl]methanol
CAS No.:1358579-69-7
Molecular Formula:C₄₇H₅₁ClO₉
Molecular Weight:795.37
Hs Code.:

[(3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-yl]methanol

Synonyms:[(3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-yl]methanol

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Chemical Property of [(3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-yl]methanol

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Technology Process of [(3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-yl]methanol

There total 13 articles about [(3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1358579-67-5
(2S,3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-formaldehyde

: 1358579-69-7
[(3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-yl]methanol

Guidance literature:: formaldehyd; (2S,3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-formaldehyde; With water; sodium hydroxide; In 1,4-dioxane; at 50 - 70 ℃; for 20h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 0.5h;

Reference yield:

: 1358579-58-4
(2S,3R,4S,5S,6R)-6-[[tert-butyl(dimethyl)silyloxy]methyl]-2-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-methoxytetrahydropyran-3,4,5-triol

: 1358579-69-7
[(3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-yl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

1.2: 16 h

2.1: acetyl chloride; methanol / 1 h

3.1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / -78 - 20 °C

4.1: sodium hydroxide; water / 1,4-dioxane / 20 h / 50 - 70 °C

4.2: 0.5 h

With methanol; oxalyl dichloride; water; sodium hydride; triethylamine; acetyl chloride; sodium hydroxide; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1358579-61-9
tert-butyldimethyl-[[(2R,3R,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-yl]methoxy]silicon

: 1358579-69-7
[(3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-yl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetyl chloride; methanol / 1 h

2.1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / -78 - 20 °C

3.1: sodium hydroxide; water / 1,4-dioxane / 20 h / 50 - 70 °C

3.2: 0.5 h

With methanol; oxalyl dichloride; water; triethylamine; acetyl chloride; sodium hydroxide; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;