tert-butyldimethyl-[[(2R,3R,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-yl]methoxy]silicon

Base Information

• Chemical Name: tert-butyldimethyl-[[(2R,3R,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-yl]methoxy]silicon
• CAS No.: 1358579-61-9
• Molecular Formula: C₅₂H₆₃ClO₈Si
• Molecular Weight: 879.606

Synonyms:tert-butyldimethyl-[[(2R,3R,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-yl]methoxy]silicon

Chemical Property of tert-butyldimethyl-[[(2R,3R,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-yl]methoxy]silicon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of tert-butyldimethyl-[[(2R,3R,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-yl]methoxy]silicon

There total 13 articles about tert-butyldimethyl-[[(2R,3R,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-yl]methoxy]silicon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3R,4S,5S,6R)-6-[[tert-butyl(dimethyl)silyloxy]methyl]-2-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-methoxytetrahydropyran-3,4,5-triol (1358579-58-4) + benzyl bromide (100-39-0) → tert-butyldimethyl-[[(2R,3R,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-yl]methoxy]silicon (1358579-61-9)

Guidance literature:

(2S,3R,4S,5S,6R)-6-[[tert-butyl(dimethyl)silyloxy]methyl]-2-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-methoxytetrahydropyran-3,4,5-triol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.25h;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; for 16h;

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyldimethyl-[[(2R,3R,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-yl]methoxy]silicon (1358579-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; dmap / 16 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

2.2: 16 h

With pyridine; dmap; sodium hydride; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

(2S,3R,4S,5S,6R)-2-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-(hydroxymethyl)-2-methoxytetrahydropyran-3,4,5-triol (1118567-46-6) → tert-butyldimethyl-[[(2R,3R,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-yl]methoxy]silicon (1358579-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; dmap / 16 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

2.2: 16 h

With pyridine; dmap; sodium hydride; In N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

tert-butyldimethylsilyl chloride

(2S,3R,4S,5S,6R)-6-[[tert-butyl(dimethyl)silyloxy]methyl]-2-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-methoxytetrahydropyran-3,4,5-triol

benzyl bromide

(2S,3R,4S,5S,6R)-2-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-(hydroxymethyl)-2-methoxytetrahydropyran-3,4,5-triol

Downstream raw materials:

(1S,2S,3S,4R,5S)-5-[4-chloro-3-[[4-[2-(cyclopropoxy)ethoxy]phenyl]methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

[(1S,2S,3S,4R,5S)-2,3,4-tri-benzyloxy-5-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6,8-dioxabicyclo[3.2.1]octan-1-yl]methanol

[(3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-yl]methanol

(2S,3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-formaldehyde

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