6-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2,3-dimethoxyphenol

Base Information

Chemical Name:6-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2,3-dimethoxyphenol
CAS No.:189825-81-8
Molecular Formula:C₂₁H₂₅N₃O₄
Molecular Weight:383.447
Hs Code.:

Synonyms:6-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2,3-dimethoxyphenol

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Chemical Property of 6-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2,3-dimethoxyphenol

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Technology Process of 6-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2,3-dimethoxyphenol

There total 10 articles about 6-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2,3-dimethoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 445474-84-0
2-azido-5-[1-(2-hydroxy-3,4-dimethoxyphenyl)methyl]-4-[1-(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole

: 189825-81-8
6-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2,3-dimethoxyphenol

Guidance literature:: With hydrogen; 10percent Pd/C; In ethanol; at 20 ℃; for 24h;
DOI:10.1039/b200845a

Reference yield:

: 122271-66-3
2-<(tert-butyldimethylsilyl)oxy>-3,4-dimethoxybenzaldehyde

: 189825-81-8
6-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2,3-dimethoxyphenol

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 78 percent / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: 98 percent / Et₃SiH; TFA / CH₂Cl₂ / 12 h / 20 °C

3.1: 81 percent / NBS / tetrahydrofuran / 1 h / 0 °C

4.1: 89 percent / t-BuLi / pentane; tetrahydrofuran / 1 h / -78 °C

5.1: 62 percent / NaBH₄; NiCl₂*6H₂O / methanol; tetrahydrofuran / 2 h / Heating

6.1: 59 percent / NBS / tetrahydrofuran / 1 h / 0 °C

7.1: t-BuLi / pentane; tetrahydrofuran / 0.25 h / -78 °C

7.2: 78 percent / trisyl azide / pentane; tetrahydrofuran / 1 h / -78 °C

8.1: 87 percent / TBAF / tetrahydrofuran / 0.08 h / 20 °C

9.1: 97 percent / H₂ / 10percent Pd/C / ethanol / 24 h / 20 °C

With 2,2,6,6-tetramethyl-piperidine; triethylsilane; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; trifluoroacetic acid; nickel dichloride; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; pentane;
DOI:10.1039/b200845a

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 189825-81-8
6-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2,3-dimethoxyphenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 89 percent / t-BuLi / pentane; tetrahydrofuran / 1 h / -78 °C

2.1: 62 percent / NaBH₄; NiCl₂*6H₂O / methanol; tetrahydrofuran / 2 h / Heating

3.1: 59 percent / NBS / tetrahydrofuran / 1 h / 0 °C

4.1: t-BuLi / pentane; tetrahydrofuran / 0.25 h / -78 °C

4.2: 78 percent / trisyl azide / pentane; tetrahydrofuran / 1 h / -78 °C

5.1: 87 percent / TBAF / tetrahydrofuran / 0.08 h / 20 °C

6.1: 97 percent / H₂ / 10percent Pd/C / ethanol / 24 h / 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; nickel dichloride; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; pentane;
DOI:10.1039/b200845a