N-(3-trifluoromethyl-4-methoxycarbonyl-5-isoxazolyl)benzenesulfonamide

Base Information

Chemical Name:N-(3-trifluoromethyl-4-methoxycarbonyl-5-isoxazolyl)benzenesulfonamide
CAS No.:178552-17-5
Molecular Formula:C₁₂H₉F₃N₂O₅S
Molecular Weight:350.275
Hs Code.:

Synonyms:N-(3-trifluoromethyl-4-methoxycarbonyl-5-isoxazolyl)benzenesulfonamide

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Chemical Property of N-(3-trifluoromethyl-4-methoxycarbonyl-5-isoxazolyl)benzenesulfonamide

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Technology Process of N-(3-trifluoromethyl-4-methoxycarbonyl-5-isoxazolyl)benzenesulfonamide

There total 3 articles about N-(3-trifluoromethyl-4-methoxycarbonyl-5-isoxazolyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 108655-61-4
methyl 5-amino-3-(trifluoromethyl)isoxazole-4-carboxylate

: 98-09-9
benzenesulfonyl chloride

: 178552-17-5
N-(3-trifluoromethyl-4-methoxycarbonyl-5-isoxazolyl)benzenesulfonamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; Ambient temperature;
DOI:10.1080/00397919808006850

Reference yield:

: 111246-08-3
1-cyano-1-methoxycarbonyl-2-trifluoromethylethylene

: 178552-17-5
N-(3-trifluoromethyl-4-methoxycarbonyl-5-isoxazolyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: NH₂OH*HCl, NaOH / H₂O / 0.33 h

2: 84 percent / NaH / tetrahydrofuran / Ambient temperature

With sodium hydroxide; hydroxylamine hydrochloride; sodium hydride; In tetrahydrofuran; water;
DOI:10.1080/00397919808006850

Reference yield:

: 207238-34-4
2-Cyano-4,4,4-trifluoro-3-oxo-butyric acid methyl ester

: 178552-17-5
N-(3-trifluoromethyl-4-methoxycarbonyl-5-isoxazolyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride, pyridine / CH₂Cl₂ / 4 h / Heating

2: NH₂OH*HCl, NaOH / H₂O / 0.33 h

3: 84 percent / NaH / tetrahydrofuran / Ambient temperature

With pyridine; sodium hydroxide; oxalyl dichloride; hydroxylamine hydrochloride; sodium hydride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1080/00397919808006850