methyl 3-hydroxy-2-{[2-(benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate

Base Information

• Chemical Name: methyl 3-hydroxy-2-{[2-(benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate
• CAS No.: 186501-26-8
• Molecular Formula: C₂₉H₂₂N₂O₆
• Molecular Weight: 494.503
• Mol file: 186501-26-8.mol

Synonyms:methyl 3-hydroxy-2-{[2-(benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate

Chemical Property of methyl 3-hydroxy-2-{[2-(benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-hydroxy-2-{[2-(benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate

There total 11 articles about methyl 3-hydroxy-2-{[2-(benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-amino-3-hydroxy-benzoic acid methyl ester (17672-21-8) + 2-(2-(benzyloxy)phenyl)benzo[d]oxazole-4-carboxylic acid (186501-25-7) → methyl 3-hydroxy-2-{[2-(benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate (186501-26-8)

Guidance literature:

2-(2-(benzyloxy)phenyl)benzo[d]oxazole-4-carboxylic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

2-amino-3-hydroxy-benzoic acid methyl ester; With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1016/S0968-0896(02)00327-9

Reference yield:

2-amino-3-hydroxy-benzoic acid methyl ester (17672-21-8) + 2-(2-Benzyloxy-phenyl)-benzooxazole-4-carbonyl chloride (153373-42-3) → methyl 3-hydroxy-2-{[2-(benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate (186501-26-8)

Guidance literature:

With pyridine; In dichloromethane; for 1h; Yield given; Ambient temperature;

DOI:10.1016/S0040-4039(96)02288-5

Reference yield:

2-(2-(benzyloxy)benzoylamino)-3-hydroxybenzoic acid methyl ester (186501-21-3) → methyl 3-hydroxy-2-{[2-(benzyloxyphenyl)-1,3-benzoxazol-4-yl]carbonyl}aminobenzoate (186501-26-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / 5 h / 230 °C / 40 Torr

2: 84 percent / sodium hydroxide / tetrahydrofuran / 2 h / Heating

3: oxalyl chloride; N,N-dimethylformamide / CH₂Cl₂ / 2 h / 20 °C

4: 0.08 g / pyridine / CH₂Cl₂

With pyridine; sodium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2006.05.007

upstream raw materials:

2-amino-3-hydroxy-benzoic acid methyl ester

2-(2-Benzyloxy-phenyl)-benzooxazole-4-carbonyl chloride

2-(2-(benzyloxy)phenyl)benzo[d]oxazole-4-carboxylic acid

2-benzyloxybenzoic acid

Downstream raw materials:

2'-(2-hydroxyphenyl)-2,4'-bibenzoxazole-4-carboxylic acid methyl ester