186501-21-3Relevant articles and documents
Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles
Huang, Shu-Ting,Hsei, I-Jen,Chen, Chinpiao
, p. 6106 - 6119 (2007/10/03)
Four classes of UK-1 analogues were synthesized and their cytotoxicity testing against human A-549, BFTC-905, RD, MES-SA, and HeLa carcinoma cell lines was determined. The results revealed that UK-1 and four of these analogues (15-18) are potent against the cancer cell lines. In particular, compound 16 is more potent than UK-1 against A-549 and HeLa cell lines, and compounds 15, 17, and 18 selectively exhibit potent cytotoxic activity against the BFTV-905 cells (IC50 9.6 μM), A-549 cells (IC50 6.6 μM), and MES-SA cells (IC50 9.2 μM), respectively.
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs
Wang, Ben B.,Maghami, Nima,Goodlin, Vanessa L.,Smith, Paul J.
, p. 3221 - 3226 (2007/10/03)
Three new analogs of UK-1 have been synthesized and their efficacies as topoisomerase II inhibitors have been determined. Results show that UK-1 and two of these analogs are catalytic inhibitors of topo II and identifies a critical structure motif necessa
The total synthesis of UK-1
DeLuca, Mark R.,Kerwin, Sean M.
, p. 199 - 202 (2007/10/03)
A concise, five-step total synthesis of UK-1, a novel bis(benzoxazole) metabolite of Streptomyces sp. 517-02, was accomplished. The methyl ether of UK-1 was also synthesized in 3 steps using the same methodology. Both syntheses are accomplished by the seq
