benzyl (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoate

Base Information

Chemical Name:benzyl (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoate
CAS No.:434343-66-5
Molecular Formula:C₄₀H₅₄O₇Si
Molecular Weight:674.95
Hs Code.:

Synonyms:benzyl (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoate

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Chemical Property of benzyl (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoate

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Technology Process of benzyl (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoate

There total 9 articles about benzyl (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30414-55-2
methyl 5-methyl-3-oxohexanoate

: 434343-66-5
benzyl (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / H₂ / [Ru((R)-binap)Cl₂] / methanol / 72 h / 20 °C / 76000 Torr

2: 74 percent / KOH / ethanol / 24 h / 0 - 20 °C

3: 93 percent / NaHCO₃ / dimethylformamide / 24 h / 20 °C

4: 77 percent / pyridine / CH₂Cl₂ / -78 °C

5: 95 percent / 70 percent HF*pyridine / CH₂Cl₂ / 0.33 h / 0 °C

6: 89 percent / pyridine / CH₂Cl₂ / -78 °C

With pyridine; potassium hydroxide; hydrogen; sodium hydrogencarbonate; pyridine hydrogenfluoride; RuCl₂[S-BINAP]; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/1522-2675(200202)85:2<633::AID-HLCA633>3.0.CO;2-1

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 434343-66-5
benzyl (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / H₂ / [Ru((R)-binap)Cl₂] / methanol / 72 h / 20 °C / 76000 Torr

2: imidazole; DMAP / dimethylformamide / 18 h / 20 °C

3: KOH / ethanol / 12 h / 0 - 20 °C

4: (COCl)2; DMF / CH₂Cl₂ / 20 °C

5: 89 percent / pyridine / CH₂Cl₂ / -78 °C

With pyridine; 1H-imidazole; dmap; potassium hydroxide; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; RuCl₂[S-BINAP]; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/1522-2675(200202)85:2<633::AID-HLCA633>3.0.CO;2-1

Reference yield:

: 86238-65-5
2,2-dimethyl-5-(3-methylbutanoyl)-1,3-dioxane-4,6-dione

: 434343-66-5
benzyl (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 4 h / Heating

2: 96 percent / H₂ / [Ru((R)-binap)Cl₂] / methanol / 72 h / 20 °C / 76000 Torr

3: 74 percent / KOH / ethanol / 24 h / 0 - 20 °C

4: 93 percent / NaHCO₃ / dimethylformamide / 24 h / 20 °C

5: 77 percent / pyridine / CH₂Cl₂ / -78 °C

6: 95 percent / 70 percent HF*pyridine / CH₂Cl₂ / 0.33 h / 0 °C

7: 89 percent / pyridine / CH₂Cl₂ / -78 °C

With pyridine; potassium hydroxide; hydrogen; sodium hydrogencarbonate; pyridine hydrogenfluoride; RuCl₂[S-BINAP]; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/1522-2675(200202)85:2<633::AID-HLCA633>3.0.CO;2-1