(3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoic acid

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Chemical Name:(3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoic acid
CAS No.:434343-67-6
Molecular Formula:C₃₃H₄₈O₇Si
Molecular Weight:584.825
Hs Code.:

Synonyms:(3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoic acid

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Chemical Property of (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoic acid

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Technology Process of (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoic acid

There total 12 articles about (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 434343-66-5
benzyl (3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoate

: 434343-67-6
(3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 28h;
DOI:10.1002/1522-2675(200202)85:2<633::AID-HLCA633>3.0.CO;2-1

Reference yield:

: 30414-55-2
methyl 5-methyl-3-oxohexanoate

: 434343-67-6
(3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / H₂ / [Ru((R)-binap)Cl₂] / methanol / 72 h / 20 °C / 76000 Torr

2: 74 percent / KOH / ethanol / 24 h / 0 - 20 °C

3: 93 percent / NaHCO₃ / dimethylformamide / 24 h / 20 °C

4: 77 percent / pyridine / CH₂Cl₂ / -78 °C

5: 95 percent / 70 percent HF*pyridine / CH₂Cl₂ / 0.33 h / 0 °C

6: 89 percent / pyridine / CH₂Cl₂ / -78 °C

7: 83 percent / H₂ / 10 percent Pd/C / methanol / 28 h

With pyridine; potassium hydroxide; hydrogen; sodium hydrogencarbonate; pyridine hydrogenfluoride; palladium on activated charcoal; RuCl₂[S-BINAP]; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/1522-2675(200202)85:2<633::AID-HLCA633>3.0.CO;2-1

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 434343-67-6
(3R)-3-{[(3'R)-3'-({(3S)-3-[(tert-butyl)diphenylsilyloxy]-4-methylpentanoyl}oxy)butanoyl]-oxy}-5-methylhexanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / H₂ / [Ru((R)-binap)Cl₂] / methanol / 72 h / 20 °C / 76000 Torr

2: imidazole; DMAP / dimethylformamide / 18 h / 20 °C

3: KOH / ethanol / 12 h / 0 - 20 °C

4: (COCl)2; DMF / CH₂Cl₂ / 20 °C

5: 89 percent / pyridine / CH₂Cl₂ / -78 °C

6: 83 percent / H₂ / 10 percent Pd/C / methanol / 28 h

With pyridine; 1H-imidazole; dmap; potassium hydroxide; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; RuCl₂[S-BINAP]; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/1522-2675(200202)85:2<633::AID-HLCA633>3.0.CO;2-1