3-(benzyloxy)-1-{2-[2-tetrahydro-2H-2-pyranyloxy]ethoxy}ethyl-2(1H)-pyridinone

Base Information

• Chemical Name: 3-(benzyloxy)-1-{2-[2-tetrahydro-2H-2-pyranyloxy]ethoxy}ethyl-2(1H)-pyridinone
• CAS No.: 238420-39-8
• Molecular Formula: C₂₁H₂₇NO₅
• Molecular Weight: 373.449
• Mol file: 238420-39-8.mol

Synonyms:3-(benzyloxy)-1-{2-[2-tetrahydro-2H-2-pyranyloxy]ethoxy}ethyl-2(1H)-pyridinone

Chemical Property of 3-(benzyloxy)-1-{2-[2-tetrahydro-2H-2-pyranyloxy]ethoxy}ethyl-2(1H)-pyridinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(benzyloxy)-1-{2-[2-tetrahydro-2H-2-pyranyloxy]ethoxy}ethyl-2(1H)-pyridinone

There total 2 articles about 3-(benzyloxy)-1-{2-[2-tetrahydro-2H-2-pyranyloxy]ethoxy}ethyl-2(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(2-bromoethoxy)tetrahydropyran (17739-45-6,59146-56-4) + 3-(benzyloxy)-1-(2-hydroxyethyl)-2(1H)-pyridinone (238420-38-7) → 3-(benzyloxy)-1-{2-[2-tetrahydro-2H-2-pyranyloxy]ethoxy}ethyl-2(1H)-pyridinone (238420-39-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; Heating;

DOI:10.1021/jo990387s

Reference yield:

2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)acetic acid (95215-72-8) → 3-(benzyloxy)-1-{2-[2-tetrahydro-2H-2-pyranyloxy]ethoxy}ethyl-2(1H)-pyridinone (238420-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / BH₃ / tetrahydrofuran / 5 h / 20 °C

2: 85 percent / NaH / tetrahydrofuran / Heating

With borane; sodium hydride; In tetrahydrofuran; 1: Reduction / 2: Etherification;

DOI:10.1021/jo990387s

Reference yield: 100.0%

3-(benzyloxy)-1-{2-[2-tetrahydro-2H-2-pyranyloxy]ethoxy}ethyl-2(1H)-pyridinone (238420-39-8) → 3-(benzyloxy)-1-[2-(2-hydroxyethoxy)ethyl]-2-(1H)-pyridinone (238420-40-1)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 8h;

DOI:10.1021/jo990387s

upstream raw materials:

2-(2-bromoethoxy)tetrahydropyran

3-(benzyloxy)-1-(2-hydroxyethyl)-2(1H)-pyridinone

2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)acetic acid

Downstream raw materials:

3-(benzyloxy)-1-[2-(2-hydroxyethoxy)ethyl]-2-(1H)-pyridinone

3-(benzyloxy)-1-(2-(2-iodoethoxy)ethyl)pyridin-2(1H)-one

3-(benzyloxy)-1-[2-(2-methanesulfonyloxyethoxy)ethyl]-2(1H)-pyridinone

25,27-bis-2-[2-(3-(benzyloxy)-2-oxo-1,2-dihydro-1-pyridyl)ethoxy]ethoxy-26,28-dihydroxy-p-tert-butylcalix[4]arene