3-(benzyloxy)-1-[2-(2-methanesulfonyloxyethoxy)ethyl]-2(1H)-pyridinone

Base Information

• Chemical Name: 3-(benzyloxy)-1-[2-(2-methanesulfonyloxyethoxy)ethyl]-2(1H)-pyridinone
• CAS No.: 238420-41-2
• Molecular Formula: C₁₇H₂₁NO₆S
• Molecular Weight: 367.423
• Mol file: 238420-41-2.mol

Synonyms:3-(benzyloxy)-1-[2-(2-methanesulfonyloxyethoxy)ethyl]-2(1H)-pyridinone

Chemical Property of 3-(benzyloxy)-1-[2-(2-methanesulfonyloxyethoxy)ethyl]-2(1H)-pyridinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(benzyloxy)-1-[2-(2-methanesulfonyloxyethoxy)ethyl]-2(1H)-pyridinone

There total 4 articles about 3-(benzyloxy)-1-[2-(2-methanesulfonyloxyethoxy)ethyl]-2(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanesulfonyl chloride (124-63-0) + 3-(benzyloxy)-1-[2-(2-hydroxyethoxy)ethyl]-2-(1H)-pyridinone (238420-40-1) → 3-(benzyloxy)-1-[2-(2-methanesulfonyloxyethoxy)ethyl]-2(1H)-pyridinone (238420-41-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2.5h;

DOI:10.1021/jo990387s

Reference yield:

2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)acetic acid (95215-72-8) → 3-(benzyloxy)-1-[2-(2-methanesulfonyloxyethoxy)ethyl]-2(1H)-pyridinone (238420-41-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / BH₃ / tetrahydrofuran / 5 h / 20 °C

2: 85 percent / NaH / tetrahydrofuran / Heating

3: 100 percent / p-TsOH / methanol / 8 h / 20 °C

4: 94 percent / Et₃N / CH₂Cl₂ / 2.5 h / 0 - 20 °C

With borane; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 1: Reduction / 2: Etherification / 3: Hydrolysis / 4: Esterification;

DOI:10.1021/jo990387s

Reference yield:

3-(benzyloxy)-1-(2-hydroxyethyl)-2(1H)-pyridinone (238420-38-7) → 3-(benzyloxy)-1-[2-(2-methanesulfonyloxyethoxy)ethyl]-2(1H)-pyridinone (238420-41-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / NaH / tetrahydrofuran / Heating

2: 100 percent / p-TsOH / methanol / 8 h / 20 °C

3: 94 percent / Et₃N / CH₂Cl₂ / 2.5 h / 0 - 20 °C

With sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 1: Etherification / 2: Hydrolysis / 3: Esterification;

DOI:10.1021/jo990387s

upstream raw materials:

methanesulfonyl chloride

3-(benzyloxy)-1-[2-(2-hydroxyethoxy)ethyl]-2-(1H)-pyridinone

2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)acetic acid

3-(benzyloxy)-1-(2-hydroxyethyl)-2(1H)-pyridinone

Downstream raw materials:

3-(benzyloxy)-1-(2-(2-iodoethoxy)ethyl)pyridin-2(1H)-one

25,27-bis-2-[2-(3-(benzyloxy)-2-oxo-1,2-dihydro-1-pyridyl)ethoxy]ethoxy-26,28-dihydroxy-p-tert-butylcalix[4]arene