(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone dimethyl acetal

Base Information

Chemical Name:(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone dimethyl acetal
CAS No.:111197-90-1
Molecular Formula:C₁₅H₂₄O₆S
Molecular Weight:332.418
Hs Code.:

Synonyms:(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone dimethyl acetal

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Chemical Property of (S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone dimethyl acetal

Chemical Property:

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Technology Process of (S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone dimethyl acetal

There total 8 articles about (S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 124-63-0
methanesulfonyl chloride

: 111197-85-4
(S)-2-hydroxy-1-(4-methoxyphenyl)-3-methyl-1-butanone dimethyl acetal

: 111197-90-1
(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone dimethyl acetal

Guidance literature:: With pyridine; for 12h; Ambient temperature;
DOI:10.1246/bcsj.60.1027

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 111197-90-1
(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone dimethyl acetal

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / sodium nitrite, 2M H₂SO₄ / H₂O

2: 81 percent / diethyl ether / ice cooling

3: 80 percent / 4-dimethylaminopyridine / 110 h / 70 °C

4: 88 percent / PPTS / CH₂Cl₂ / from 0 deg C to rt

5: 85 percent / tetrahydrofuran / 1 h / ice cooling

6: 97 percent / PPTS / ethanol / 6 h

7: 72 percent / methanesulfonic acid / methanol / 1 h / ice cooling

8: 90 percent / pyridine / 12 h / Ambient temperature

With pyridine; dmap; methanesulfonic acid; sulfuric acid; pyridinium p-toluenesulfonate; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1246/bcsj.60.1027

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 111197-90-1
(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone dimethyl acetal

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / diethyl ether / ice cooling

2: 80 percent / 4-dimethylaminopyridine / 110 h / 70 °C

3: 88 percent / PPTS / CH₂Cl₂ / from 0 deg C to rt

4: 85 percent / tetrahydrofuran / 1 h / ice cooling

5: 97 percent / PPTS / ethanol / 6 h

6: 72 percent / methanesulfonic acid / methanol / 1 h / ice cooling

7: 90 percent / pyridine / 12 h / Ambient temperature

With pyridine; dmap; methanesulfonic acid; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1246/bcsj.60.1027