6-(2-Fluorophenyl)-4-(indol-2-yl)carbonylamino-1-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

Base Information

Chemical Name:6-(2-Fluorophenyl)-4-(indol-2-yl)carbonylamino-1-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine
CAS No.:111139-85-6
Molecular Formula:C₂₆H₁₉FN₆O
Molecular Weight:450.475
Hs Code.:

Synonyms:6-(2-Fluorophenyl)-4-(indol-2-yl)carbonylamino-1-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

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Chemical Property of 6-(2-Fluorophenyl)-4-(indol-2-yl)carbonylamino-1-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

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Technology Process of 6-(2-Fluorophenyl)-4-(indol-2-yl)carbonylamino-1-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

There total 7 articles about 6-(2-Fluorophenyl)-4-(indol-2-yl)carbonylamino-1-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1445-45-0
Trimethyl orthoacetate

: 111113-23-6
N-<5-(2-fluorophenyl)-2-hydrazono-3H-1,4-benzodiazepin-3-yl>-1H-indole-2-carboxamide

: 111139-85-6
6-(2-Fluorophenyl)-4-(indol-2-yl)carbonylamino-1-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

Guidance literature:: With sulfuric acid; In ethanol; for 10h; Ambient temperature;
DOI:10.1021/jm00396a028

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 111139-85-6
6-(2-Fluorophenyl)-4-(indol-2-yl)carbonylamino-1-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, Et₃N / dimethylformamide / 18 h / Ambient temperature; pH 8

2: NH₂NH₂ / methanol / 1.5 h / 23 °C

3: 68 percent / H₂SO₄ / ethanol / 10 h / Ambient temperature

With sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; hydrazine; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00396a028

Reference yield:

: 103373-52-0
(3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

: 111139-85-6
6-(2-Fluorophenyl)-4-(indol-2-yl)carbonylamino-1-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / Lawesson's reagent / toluene / 1.5 h / Heating

2: HBr gas / CH₂Cl₂; acetic acid / 6 h

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, Et₃N / dimethylformamide / 18 h / Ambient temperature; pH 8

4: NH₂NH₂ / methanol / 1.5 h / 23 °C

5: 68 percent / H₂SO₄ / ethanol / 10 h / Ambient temperature

With Lawessons reagent; sulfuric acid; hydrogen bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; hydrazine; In methanol; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00396a028