(4S,5S)-4,5-dihydro-4,5-diphenyl-2-(2'-hydroxy-3'-tert-butylphenyl)-oxazoline

Base Information

• Chemical Name: (4S,5S)-4,5-dihydro-4,5-diphenyl-2-(2'-hydroxy-3'-tert-butylphenyl)-oxazoline
• CAS No.: 340131-68-2
• Molecular Formula: C₂₅H₂₅NO₂
• Molecular Weight: 371.479
• Mol file: 340131-68-2.mol

Synonyms:(4S,5S)-4,5-dihydro-4,5-diphenyl-2-(2'-hydroxy-3'-tert-butylphenyl)-oxazoline

Chemical Property of (4S,5S)-4,5-dihydro-4,5-diphenyl-2-(2'-hydroxy-3'-tert-butylphenyl)-oxazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,5S)-4,5-dihydro-4,5-diphenyl-2-(2'-hydroxy-3'-tert-butylphenyl)-oxazoline

There total 1 articles about (4S,5S)-4,5-dihydro-4,5-diphenyl-2-(2'-hydroxy-3'-tert-butylphenyl)-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(1S,2S)-2-amino-1,2-diphenylethanol (530-36-9,3764-63-4,13286-63-0,23190-16-1,23190-17-2,23364-44-5,23412-95-5,39664-87-4,88082-66-0) + 2-hydroxy-3-tert-butyl benzonitrile (340131-70-6) → (4S,5S)-4,5-dihydro-4,5-diphenyl-2-(2'-hydroxy-3'-tert-butylphenyl)-oxazoline (340131-68-2)

Guidance literature:

With zinc(II) chloride; In chlorobenzene; for 20h; Heating;

DOI:10.1016/S0022-328X(00)00687-2

Reference yield: 82.0%

copper(II) acetate monohydrate (6046-93-1) + (4S,5S)-4,5-dihydro-4,5-diphenyl-2-(2'-hydroxy-3'-tert-butylphenyl)-oxazoline (340131-68-2) → bis[(4S,5S)-4,5-dihydro-4,5-diphenyl-2-(2'-oxido-3'-tert-butylphenyl-χO)oxazole-χN]copper(II)

Guidance literature:

In ethanol; addn. of a soln. of copper acetate in abs. ethanol to a soln. of ligand in abs. ethanol, stirring at room temp. for 16 h; filtration, washing with abs. ethanol three times; elem. anal.;

DOI:10.1016/S0022-328X(00)00687-2

upstream raw materials:

(1S,2S)-2-amino-1,2-diphenylethanol

2-hydroxy-3-tert-butyl benzonitrile