(E)-1-[4-(2-chlorovinyl)phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:(E)-1-[4-(2-chlorovinyl)phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester
CAS No.:1259940-18-5
Molecular Formula:C₁₃H₁₂ClN₃O₂
Molecular Weight:277.71
Hs Code.:

Synonyms:(E)-1-[4-(2-chlorovinyl)phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

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Chemical Property of (E)-1-[4-(2-chlorovinyl)phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

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Technology Process of (E)-1-[4-(2-chlorovinyl)phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

There total 5 articles about (E)-1-[4-(2-chlorovinyl)phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1259939-90-6
(E)-1-azido-4-(2-chlorovinyl)benzene

: 623-47-2
propynoic acid ethyl ester

: 1259940-18-5
(E)-1-[4-(2-chlorovinyl)phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Guidance literature:: With copper(l) iodide; sodium L-ascorbate; In dimethyl sulfoxide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1007/s11172-010-0100-9

Reference yield: 90.0%

: 133463-51-1
(E)-3-(4-azidophenyl)acrylic acid

: 623-47-2
propynoic acid ethyl ester

: 1259940-18-5
(E)-1-[4-(2-chlorovinyl)phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Guidance literature:: With N-chloro-succinimide; copper(l) iodide; lithium acetate; sodium L-ascorbate; In water; acetonitrile; at 80 ℃; for 8h; optical yield given as %de; stereoselective reaction; Inert atmosphere;
DOI:10.1080/00397911.2010.481746

Reference yield:

: 882-06-4
4-nitro-trans-cinnamic acid

: 1259940-18-5
(E)-1-[4-(2-chlorovinyl)phenyl]-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; zinc / water / 0.5 h / 20 °C

2: sodium nitrite / water / 0.17 h / 0 °C

3: N-chloro-succinimide; copper(l) iodide; lithium acetate; sodium L-ascorbate / water; acetonitrile / 8 h / 80 °C / Inert atmosphere

With N-chloro-succinimide; copper(l) iodide; lithium acetate; acetic acid; sodium L-ascorbate; zinc; sodium nitrite; In water; acetonitrile;
DOI:10.1080/00397911.2010.481746