cis-4-[4-(5-cyclopentylamino[1,3,4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylic acid

Base Information

Chemical Name:cis-4-[4-(5-cyclopentylamino[1,3,4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylic acid
CAS No.:1334425-54-5
Molecular Formula:C₂₁H₂₆N₄O₄S
Molecular Weight:430.528
Hs Code.:

Synonyms:cis-4-[4-(5-cyclopentylamino[1,3,4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylic acid

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Chemical Property of cis-4-[4-(5-cyclopentylamino[1,3,4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylic acid

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Technology Process of cis-4-[4-(5-cyclopentylamino[1,3,4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylic acid

There total 7 articles about cis-4-[4-(5-cyclopentylamino[1,3,4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239311-38-6
methyl cis-4-[4-(5-cyclopentylamino[1.3.4]thiadiazol-2-ylcarbamoyl)-phenoxy]cyclohexanecarboxylate

: 1334425-54-5
cis-4-[4-(5-cyclopentylamino[1,3,4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylic acid

Guidance literature:: methyl cis-4-[4-(5-cyclopentylamino[1.3.4]thiadiazol-2-ylcarbamoyl)-phenoxy]cyclohexanecarboxylate; With sodium hydroxide; In tetrahydrofuran; methanol; for 18h;

With sulfur dioxide; In water;

Reference yield:

: 25804-49-3
tert-butyl 4-hydroxybenzoate

: 1334425-54-5
cis-4-[4-(5-cyclopentylamino[1,3,4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

2: trifluoroacetic acid / dichloromethane; diethyl ether / 5 h / 4 - 20 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

4: pyridine / acetonitrile / 72 h / Inert atmosphere

5: sodium hydroxide / tetrahydrofuran; methanol / 18 h

With pyridine; oxalyl dichloride; di-isopropyl azodicarboxylate; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 3618-03-9,17449-76-2,6125-57-1
trans-4-hydroxycyclohexane-1-carboxylic acid methyl ester

: 1334425-54-5
cis-4-[4-(5-cyclopentylamino[1,3,4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

2: trifluoroacetic acid / dichloromethane; diethyl ether / 5 h / 4 - 20 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

4: pyridine / acetonitrile / 72 h / Inert atmosphere

5: sodium hydroxide / tetrahydrofuran; methanol / 18 h

With pyridine; oxalyl dichloride; di-isopropyl azodicarboxylate; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;