Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester, cis-

Base Information

• Chemical Name: Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester, cis-
• CAS No.: 3618-03-9
• Molecular Formula: C8H14O3
• Molecular Weight: 158.197
• Hs Code.: 2918199090
• Mol file: 3618-03-9.mol

Synonyms:METHYL 4-HYDROXYCYCLOHEXANE-1-CARBOXYLATE;4-hydroxy-cyclohexane carboxylic acid methyl ester;4-Carbomethoxycyclohexanol;Cyclohexanecarboxylic acid,4-hydroxy-,methyl ester;HYDROXYCYCLOHEXANECARBOXYLIC ACID METHYL ESTER;methyl 4-hydroxy-1-cyclohexanecarboxylate;cyclohexanol-4-carboxylic acid methyl ester;methyl-4-hydroxycyclohexane carboxylate;

Chemical Property of Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester, cis-

Chemical Property:

• Refractive Index: 1.4705 (589.3 nm 21.5℃)
• Boiling Point: 233.3±33.0℃ (760 Torr)
• PKA: 14.96±0.40(Predicted)
• Flash Point: 93.5±18.2℃
• PSA: 46.53000
• Density: 1.121±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 0.71050
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl cis-4-hydroxycyclohexanecarboxylate 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester, cis-

There total 23 articles about Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 4-hydroxycyclohexanecarboxylic acid (3685-22-1,3685-26-5,17419-81-7) → methyl 4-hydroxycyclohexanecarboxylate (3618-03-9,6125-57-1,17449-76-2)

Guidance literature:

With thionyl chloride; at 20 - 70 ℃; for 18h;

Reference yield: 98.0%

→ methyl 4-hydroxycyclohexanecarboxylate (3618-03-9,6125-57-1,17449-76-2)

Guidance literature:

Reference yield: 97.0%

trans-4-hydroxycyclohexanecarboxylic acid (3685-26-5) + diazomethyl-trimethyl-silane (18107-18-1) → trans-4-hydroxycyclohexane-1-carboxylic acid methyl ester (3618-03-9,17449-76-2,6125-57-1)

Guidance literature:

In methanol; toluene; for 0.416667h;

upstream raw materials:

diazomethane

trans-4-hydroxycyclohexanecarboxylic acid

methyl 4-hydroxylbenzoate

4-oxocyclohexanecarboxylic acid

Downstream raw materials:

trans-4-(phenoxy)cyclohexanecarboxylic acid methyl ester

methyl cis-4-{4-[5-(3-chlorophenyl)[1.3.4]thiadiazol-2-ylcarbamoyl]phenoxy}cyclohexanecarboxylate

cis-4-{4-[5-(3-chlorophenyl)[1,3,4]thiadiazol-2-ylcarbamoyl]phenoxy}cyclohexanecarboxylic acid

methyl cis-4-[4-(5-cyclopentylamino[1.3.4]thiadiazol-2-ylcarbamoyl)-phenoxy]cyclohexanecarboxylate

Refernces

• 1、 -. "Dihydropyrimidine compound and uses of dihydropyrimidine compound in drugs". Paragraph 0764; 0765; 0766; 0767. . Retrieved 2019/01/16.
• 2、 -. "SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF". Page/Page column 50-51. . Retrieved 2018/03/09.