2-Methyl-2-(2-nitrophenyl)propanoicacid

Base Information

• Chemical Name: 2-Methyl-2-(2-nitrophenyl)propanoicacid
• CAS No.: 126802-52-6
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.202
• Mol file: 126802-52-6.mol

Synonyms:2-methyl-2-(2-nitrophenyl)propanoic acid

Chemical Property of 2-Methyl-2-(2-nitrophenyl)propanoicacid

Chemical Property:

• Vapor Pressure: 6.58E-06mmHg at 25°C
• Melting Point: 146-148 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 363.1±25.0 °C(Predicted)
• PKA: 4.01±0.10(Predicted)
• Density: 1.286±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

2-Methyl-2-(2-nitrophenyl)propanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-2-(2-nitrophenyl)propanoicacid

There total 3 articles about 2-Methyl-2-(2-nitrophenyl)propanoicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-methyl-2-(2-nitro-phenyl)-propionic acid methyl ester (136764-87-9) → 2-methyl-2-(2-nitrophenyl)propanoic acid (126802-52-6)

Guidance literature:

With water; sodium hydroxide; In methanol; for 48h; Reflux;

Reference yield:

4-(2-cyanoprop-2-yl)-1-nitrobenzene (71825-51-9) → 2-methyl-2-(2-nitrophenyl)propanoic acid (126802-52-6)

Guidance literature:

With sulfuric acid;

Reference yield:

2-methyl-2-phenylpropionitrile (1195-98-8) → 2-methyl-2-(2-nitrophenyl)propanoic acid (126802-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous HNO₃

2: aqueous H₂SO₄

With sulfuric acid; nitric acid;

upstream raw materials:

2-methyl-2-(2-nitro-phenyl)-propionic acid methyl ester

4-(2-cyanoprop-2-yl)-1-nitrobenzene

2-methyl-2-phenylpropionitrile

Downstream raw materials:

2,2-dimethyl-2-(2-nitrophenyl)acetyl chloride