METHYL 2-METHYL-2-(2-NITROPHENYL)PROPIONATE

Base Information

• Chemical Name: METHYL 2-METHYL-2-(2-NITROPHENYL)PROPIONATE
• CAS No.: 136764-87-9
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.229
• Hs Code.: 2916399090
• Mol file: 136764-87-9.mol

Synonyms:METHYL 2-METHYL-2-(2-NITROPHENYL)PROPIONATE

Chemical Property of METHYL 2-METHYL-2-(2-NITROPHENYL)PROPIONATE

Chemical Property:

• PSA: 72.12000
• LogP: 2.56860
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Methyl2-Methyl-2-(2-Nitrophenyl)propionate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of METHYL 2-METHYL-2-(2-NITROPHENYL)PROPIONATE

There total 1 articles about METHYL 2-METHYL-2-(2-NITROPHENYL)PROPIONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (2-nitrophenyl)acetate (30095-98-8) + methyl iodide (74-88-4) → 2-methyl-2-(2-nitro-phenyl)-propionic acid methyl ester (136764-87-9)

Guidance literature:

With 15-crown-5; sodium hydride; In N,N-dimethyl-formamide; at -4 - 4 ℃;

DOI:10.1016/S0968-0896(03)00426-7

Reference yield: 95.0%

2-methyl-2-(2-nitro-phenyl)-propionic acid methyl ester (136764-87-9) → 2-methyl-2-(2-nitrophenyl)propan-1-ol s10-1 (91413-88-6)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at 0 ℃; for 3h;

DOI:10.1016/j.chempr.2021.04.005

Reference yield: 94.0%

2-methyl-2-(2-nitro-phenyl)-propionic acid methyl ester (136764-87-9) → 2-methyl-2-(2-nitrophenyl)propanoic acid (126802-52-6)

Guidance literature:

With water; sodium hydroxide; In methanol; for 48h; Reflux;

upstream raw materials:

methyl (2-nitrophenyl)acetate

methyl iodide

Downstream raw materials:

2-methyl-2-(2-nitrophenyl)propanoic acid

3,3-dimethyloxindole

2,2-dimethyl-2-(2-nitrophenyl)acetyl chloride

2-(2-Amino-phenyl)-N-phenyl-isobutyramide

Refernces

• 1、 Chen, Jiangwei,Cheng, Hong-Gang,Hong, Xin,Hua, Yu,Liu, Ze-Shui,Ma, Yuanyuan,Wu, Chenggui,Xie, Pei-Pei,Zhou, Qianghui. "An axial-to-axial chirality transfer strategy for atroposelective construction of C–N axial chirality". supporting information. p. 1917 - 1932. Retrieved 2021/05/31.
• 2、 Liu, Hui,Zhou, Si-Yu,Wen, Guo-En,Liu, Xu-Xue,Liu, De-Yong,Zhang, Qing-Ju,Schmidt, Richard R.,Sun, Jian-Song. "The 2,2-Dimethyl-2-(ortho-nitrophenyl)acetyl (DMNPA) Group: A Novel Protecting Group in Carbohydrate Chemistry". supporting information. p. 8049 - 8052. Retrieved 2019/10/11.