1'-(2-benzyloxy-benzoyl)-3-formyl-1'H-[4,7']biindolyl-1,3'-dicarboxylic acid 1-tert-butyl ester 3'-methyl ester

Base Information

• Chemical Name: 1'-(2-benzyloxy-benzoyl)-3-formyl-1'H-[4,7']biindolyl-1,3'-dicarboxylic acid 1-tert-butyl ester 3'-methyl ester
• CAS No.: 473919-00-5
• Molecular Formula: C₃₈H₃₂N₂O₇
• Molecular Weight: 628.681
• Mol file: 473919-00-5.mol

Synonyms:1'-(2-benzyloxy-benzoyl)-3-formyl-1'H-[4,7']biindolyl-1,3'-dicarboxylic acid 1-tert-butyl ester 3'-methyl ester

Chemical Property of 1'-(2-benzyloxy-benzoyl)-3-formyl-1'H-[4,7']biindolyl-1,3'-dicarboxylic acid 1-tert-butyl ester 3'-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1'-(2-benzyloxy-benzoyl)-3-formyl-1'H-[4,7']biindolyl-1,3'-dicarboxylic acid 1-tert-butyl ester 3'-methyl ester

There total 4 articles about 1'-(2-benzyloxy-benzoyl)-3-formyl-1'H-[4,7']biindolyl-1,3'-dicarboxylic acid 1-tert-butyl ester 3'-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-(tert-butoxycarbonyl)-4-iodoindole-3-carboxaldehyde + 1-(2-benzyloxy-benzoyl)-7-iodo-1H-indole-3-carboxylic acid methyl ester (473918-99-9) → 1'-(2-benzyloxy-benzoyl)-3-formyl-1'H-[4,7']biindolyl-1,3'-dicarboxylic acid 1-tert-butyl ester 3'-methyl ester (473919-00-5)

Guidance literature:

1-(2-benzyloxy-benzoyl)-7-iodo-1H-indole-3-carboxylic acid methyl ester; With isopropylmagnesium chloride;

With zinc dibromide;

1-(tert-butoxycarbonyl)-4-iodoindole-3-carboxaldehyde; With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; trifuran-2-yl-phosphane; Further stages.;

DOI:10.1021/ol026694t

Reference yield:

7-iodo-1H-indole (89976-15-8) → 1'-(2-benzyloxy-benzoyl)-3-formyl-1'H-[4,7']biindolyl-1,3'-dicarboxylic acid 1-tert-butyl ester 3'-methyl ester (473919-00-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: POCl₃

2.1: sodium cyanide; manganese(IV) oxide

3.1: lithium bis(trimethylsilyl)amide

4.1: isopropylmagnesium chloride

4.2: zinc bromide

4.3: 73 percent / tris(2-furyl)phosphine; Pd₂(dba)3

With sodium cyanide; manganese(IV) oxide; isopropylmagnesium chloride; lithium hexamethyldisilazane; trichlorophosphate; 4.3: Negishi coupling;

DOI:10.1021/ol026694t

Reference yield:

methyl 7-iodoindole-3-carboxylate (123020-21-3) → 1'-(2-benzyloxy-benzoyl)-3-formyl-1'H-[4,7']biindolyl-1,3'-dicarboxylic acid 1-tert-butyl ester 3'-methyl ester (473919-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium bis(trimethylsilyl)amide

2.1: isopropylmagnesium chloride

2.2: zinc bromide

2.3: 73 percent / tris(2-furyl)phosphine; Pd₂(dba)3

With isopropylmagnesium chloride; lithium hexamethyldisilazane; 2.3: Negishi coupling;

DOI:10.1021/ol026694t

upstream raw materials:

1-(2-benzyloxy-benzoyl)-7-iodo-1H-indole-3-carboxylic acid methyl ester

7-iodo-1H-indole

methyl 7-iodoindole-3-carboxylate

7-iodo-1H-indole-3-carbaldehyde