tert-butyl 4-methylidenecyclohexanecarboxylate

Base Information

• Chemical Name: tert-butyl 4-methylidenecyclohexanecarboxylate
• CAS No.: 856680-45-0
• Molecular Formula: C₁₂H₂₀O₂
• Molecular Weight: 196.29
• Mol file: 856680-45-0.mol

Synonyms:tert-butyl 4-methylidenecyclohexanecarboxylate

Chemical Property of tert-butyl 4-methylidenecyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of tert-butyl 4-methylidenecyclohexanecarboxylate

There total 1 articles about tert-butyl 4-methylidenecyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Methyltriphenylphosphonium bromide (1779-49-3) + 4-oxocyclohexanecarboxylic acid tert-butyl ester (38446-95-6) → tert-butyl 4-methylidenecyclohexanecarboxylate (856680-45-0)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane;

4-oxocyclohexanecarboxylic acid tert-butyl ester; In tetrahydrofuran; hexane; at 0 ℃; for 1h;

DOI:10.1016/j.tet.2005.05.006

Reference yield:

tert-butyl 4-methylidenecyclohexanecarboxylate (856680-45-0) → tert-butyl 4-allyl-4-(hydroxymethyl)cyclohexanecarboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / m-CPBA; NaHCO₃ / CH₂Cl₂ / 2 h / 20 °C

2: 49 percent / chlorotitanium triphenoxide / tetrahydrofuran; diethyl ether / 3 h / -78 - 0 °C

With titanium monochloride triphenoxide; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.tet.2005.05.006

upstream raw materials:

Methyltriphenylphosphonium bromide

4-oxocyclohexanecarboxylic acid tert-butyl ester