2-CHLOROBIPHENYLENE

Base Information

Chemical Name:2-CHLOROBIPHENYLENE
CAS No.:50558-21-9
Molecular Formula:C₁₂H₇Cl
Molecular Weight:186.641
Hs Code.:2903999090
Mol file:50558-21-9.mol

Synonyms:2-Chlorobiphenylene;

Suppliers and Price of 2-CHLOROBIPHENYLENE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chlorobiphenylene
10mg
$ 1320.00

American Custom Chemicals Corporation
2-CHLOROBIPHENYLENE 95.00%
5MG
$ 495.64

Total 5 raw suppliers

Chemical Property of 2-CHLOROBIPHENYLENE

Chemical Property:

Vapor Pressure:5.28E-10mmHg at 25°C
Melting Point:65-66 °C
Refractive Index:1.7
Boiling Point:509.7 °C at 760 mmHg
Flash Point:255.9 °C
PSA：0.00000
Density:1.32 g/cm³
LogP:3.98740

Purity/Quality:

99% ^*data from raw suppliers

2-Chlorobiphenylene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-Chlorobiphenylene is a standard for environmental testing and research, also performs a chlorinated biphenylenes structure-dependent effect on Ah receptor and CYP.

Technology Process of 2-CHLOROBIPHENYLENE

There total 12 articles about 2-CHLOROBIPHENYLENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2'-bromo-4-chloro-2-fluorobiphenyl

: 50558-21-9
2-chlorobiphenylene

Guidance literature:: 2'-bromo-4-chloro-2-fluorobiphenyl; With tert.-butyl lithium; In diethyl ether; pentane; at -100 - -78 ℃; for 1h;

In diethyl ether; toluene; pentane; at -78 - -50 ℃; for 1h;

In methanol; diethyl ether; toluene; pentane; at -50 - 20 ℃; for 1h;
DOI:10.1002/anie.201708892

Reference yield:

: 160591-91-3
4-chloro-2-fluorophenylboronic acid

: 50558-21-9
2-chlorobiphenylene

: 39224-18-5
4-chloro-2-fluoro-1,1'-biphenyl

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; tetrabutylammomium bromide / ethanol; water; tetrahydrofuran / 24 h / 60 °C / Inert atmosphere; Sealed tube

2: tert.-butyl lithium / toluene; diethyl ether / 2 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; tert.-butyl lithium; sodium carbonate; In tetrahydrofuran; diethyl ether; ethanol; water; toluene; 1: |Suzuki Coupling;
DOI:10.1002/anie.201708892

Reference yield:

: 6797-79-1
4-chloro-2-fluoro-1-iodobenzene

: 50558-21-9
2-chlorobiphenylene

: 39224-18-5
4-chloro-2-fluoro-1,1'-biphenyl

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; tetrabutylammomium bromide / ethanol; water; tetrahydrofuran / 24 h / 60 °C / Inert atmosphere; Sealed tube

3.1: tert.-butyl lithium / toluene; diethyl ether / 2 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; tert.-butyl lithium; isopropylmagnesium bromide; sodium carbonate; In tetrahydrofuran; diethyl ether; ethanol; water; toluene; 2.1: |Suzuki Coupling;
DOI:10.1002/anie.201708892