5-thiazolecarboxylic methyl ester 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]-2-phenyl

Base Information

• Chemical Name: 5-thiazolecarboxylic methyl ester 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]-2-phenyl
• CAS No.: 1243140-49-9
• Molecular Formula: C₂₀H₂₁N₂O₄PS
• Molecular Weight: 416.438
• Mol file: 1243140-49-9.mol

Synonyms:5-thiazolecarboxylic methyl ester 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]-2-phenyl

Chemical Property of 5-thiazolecarboxylic methyl ester 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]-2-phenyl

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-thiazolecarboxylic methyl ester 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]-2-phenyl

There total 1 articles about 5-thiazolecarboxylic methyl ester 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]-2-phenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

(2,4-dimethyl-phenyl)-phosphonic acid methyl ester (1198089-62-1) + 4-Amino-2-phenyl-5-thiazolcarbonsaeure-methylester (99967-80-3) → 5-thiazolecarboxylic methyl ester 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]-2-phenyl (1243140-49-9)

Guidance literature:

(2,4-dimethyl-phenyl)-phosphonic acid methyl ester; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; Inert atmosphere;

4-Amino-2-phenyl-5-thiazolcarbonsaeure-methylester; With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

Reference yield: 36.0%

5-thiazolecarboxylic methyl ester 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]-2-phenyl (1243140-49-9) → 5-thiazolecarboxylic acid 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]-2-phenyl (1243141-13-0)

Guidance literature:

With potassium tert-butylate; water; In tetrahydrofuran; at 20 ℃; for 2h;

upstream raw materials:

(2,4-dimethyl-phenyl)-phosphonic acid methyl ester

4-Amino-2-phenyl-5-thiazolcarbonsaeure-methylester

Downstream raw materials:

5-thiazolecarboxylic acid 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]-2-phenyl