P-(2,4-Dimethylphenyl)phosphonic acid momomethyl ester

Base Information

• Chemical Name: P-(2,4-Dimethylphenyl)phosphonic acid momomethyl ester
• CAS No.: 1198089-62-1
• Molecular Formula: C9H13O3P
• Molecular Weight: 200.174
• Mol file: 1198089-62-1.mol

Synonyms:P-(2,4-Dimethylphenyl)phosphonic acid momomethyl ester

Chemical Property of P-(2,4-Dimethylphenyl)phosphonic acid momomethyl ester

Chemical Property:

• Boiling Point: 311.5±52.0 °C(Predicted)
• PKA: 2.36±0.58(Predicted)
• PSA: 56.34000
• Density: 1.18
• LogP: 1.76050

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of P-(2,4-Dimethylphenyl)phosphonic acid momomethyl ester

There total 2 articles about P-(2,4-Dimethylphenyl)phosphonic acid momomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,4-Xylolphosphonsaeuredimethylester → (2,4-dimethyl-phenyl)-phosphonic acid methyl ester (1198089-62-1)

Guidance literature:

2,4-Xylolphosphonsaeuredimethylester; With water; sodium hydroxide; In ethanol; at 20 ℃; for 48h;

With hydrogenchloride; In water; pH=1;

Reference yield:

1-iodo-2,4-dimethylbenzene (4214-28-2) → (2,4-dimethyl-phenyl)-phosphonic acid methyl ester (1198089-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate / acetonitrile / 0.75 h / 160 °C / Microwave irradiation

2: sodium hydroxide / methanol; water / 48 h / 20 °C

With palladium diacetate; sodium hydroxide; In methanol; water; acetonitrile;

DOI:10.1016/j.bmcl.2016.01.042

Reference yield: 69.0%

5-(4-bromo-phenyl)-thiophen-3-ylamine (1243142-33-7) + (2,4-dimethyl-phenyl)-phosphonic acid methyl ester (1198089-62-1) → 4-N-[(2,4-dimethytohenyl)-phosphonamidate methyl ester]-2-(4-bromo-phenyl)-thiophene (1243142-35-9)

Guidance literature:

(2,4-dimethyl-phenyl)-phosphonic acid methyl ester; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; Inert atmosphere;

5-(4-bromo-phenyl)-thiophen-3-ylamine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃;

upstream raw materials:

1-iodo-2,4-dimethylbenzene

Downstream raw materials:

2-thiophenecarboxylic methylester 3-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]-5-(4-fluorophenyl)

5-thiazolecarboxylic methyl ester 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]

5-thiazolecarboxylic methyl ester 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester]-2-phenyl

4-N-[(2,4-dimethytohenyl)-phosphonamidate methyl ester]-2-(4-bromo-phenyl)-thiophene

Refernces

• 1、 -. "PHOSPHOTHIOPHENE AND PHOSPHOTHIAZOLE HCV POLYMERASE INHIBITORS". Page/Page column 148. . Retrieved 2010/09/18.