1198089-62-1Relevant articles and documents
Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase
Pierra Rouvière, Claire,Amador, Agnès,Badaroux, Eric,Convard, Thierry,Da Costa, Daniel,Dukhan, David,Griffe, Ludovic,Griffon, Jean-Fran?ois,LaColla, Massimiliano,Leroy, Frédéric,Liuzzi, Michel,Loi, Anna Giulia,McCarville, Joe,Mascia, Valeria,Milhau, Julien,Onidi, Loredana,Paparin, Jean-Laurent,Rahali, Rachid,Sais, Efisio,Seifer, Maria,Surleraux, Dominique,Standring, David,Dousson, Cyril
, p. 4536 - 4541 (2016)
The hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian cells and, as a consequence, is an attractive target for selective inhibition. This Letter descr