1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethenyl]benzene

Base Information

Chemical Name:1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethenyl]benzene
CAS No.:130247-16-4
Molecular Formula:C₃₁H₄₀N₂O₈Si
Molecular Weight:596.753
Hs Code.:

1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethenyl]benzene

Synonyms:1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethenyl]benzene

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Chemical Property of 1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethenyl]benzene

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Technology Process of 1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethenyl]benzene

There total 5 articles about 1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethenyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 130247-01-7
methyl 2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)acrylate

: 130274-20-3
1-<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-4-bromobenzene

: 130247-16-4
1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethenyl]benzene

Guidance literature:: With tetrabutyl-ammonium chloride; sodium hydrogencarbonate; palladium diacetate; In N,N-dimethyl-formamide; at 85 ℃; for 16h;
DOI:10.1021/jo00003a065

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 130247-16-4
1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethenyl]benzene

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / Bu₄NCl, NaHCO₃ / Pd(OAc)2 / dimethylformamide / 16 h / 85 °C

2: 62 percent / Bu₄NCl, NaHCO₃ / Pd(OAc)2 / dimethylformamide / 16 h / 85 °C

With tetrabutyl-ammonium chloride; sodium hydrogencarbonate; palladium diacetate; In N,N-dimethyl-formamide;
DOI:10.1021/jo00003a065

Reference yield:

: 94882-75-4
benzyl (2-t-butoxycarbonylamino)acrylate

: 130247-16-4
1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethenyl]benzene

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / Bu₄NCl, NaHCO₃ / Pd(OAc)2 / dimethylformamide / 16 h / 85 °C

2: 62 percent / Bu₄NCl, NaHCO₃ / Pd(OAc)2 / dimethylformamide / 16 h / 85 °C

With tetrabutyl-ammonium chloride; sodium hydrogencarbonate; palladium diacetate; In N,N-dimethyl-formamide;
DOI:10.1021/jo00003a065