Technology Process of 4,4,4-trifluoro-3-(5-fluoro-2-propoxyphenylamino)buta-2-enoic acid ethyl ester
There total 4 articles about 4,4,4-trifluoro-3-(5-fluoro-2-propoxyphenylamino)buta-2-enoic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
toluene;
for 4h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 5%-palladium/activated carbon / ethanol / 20 °C / 760.05 Torr
2: triethylamine / dichloromethane / 1 h / 0 - 20 °C
3: toluene / 4 h / Heating / reflux
With
triethylamine;
5%-palladium/activated carbon;
In
ethanol; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C
2: 5%-palladium/activated carbon / ethanol / 20 °C / 760.05 Torr
3: triethylamine / dichloromethane / 1 h / 0 - 20 °C
4: toluene / 4 h / Heating / reflux
With
potassium carbonate; triethylamine;
5%-palladium/activated carbon;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
