Pyrazolo[1,5-a]pyridine-3-carbonyl chloride

Base Information

• Chemical Name: Pyrazolo[1,5-a]pyridine-3-carbonyl chloride
• CAS No.: 78933-24-1
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.59
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID20383685
• Wikidata: Q82175476
• Mol file: 78933-24-1.mol

Synonyms:pyrazolo[1,5-a]pyridine-3-carbonyl chloride;78933-24-1;Pyrazolo[1,5-a]pyridine-3-carbonylchloride;SCHEMBL1044120;DTXSID20383685;OBAHAHYHAQTEHP-UHFFFAOYSA-N;AMY22228;MFCD06200860;AKOS006344480;FT-0693898;Pyrazolo[1.5-a]pyridine-3-carbonyl chloride;J-524080;Pyrazolo[1,5-a]pyridine-3-carbonyl chloride, AldrichCPR

Chemical Property of Pyrazolo[1,5-a]pyridine-3-carbonyl chloride

Chemical Property:

• Melting Point: 116 °C
• Refractive Index: 1.662
• PSA: 34.37000
• Density: 1.42 g/cm³
• LogP: 1.71330
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 180.0090405
• Heavy Atom Count: 12
• Complexity: 198

Purity/Quality:

98%Min ^*data from raw suppliers

PYRAZOLO[1,5-A]PYRIDINE-3-CARBONYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=NN2C=C1)C(=O)Cl

Technology Process of Pyrazolo[1,5-a]pyridine-3-carbonyl chloride

There total 1 articles about Pyrazolo[1,5-a]pyridine-3-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrazolo[1,5-a]pyridine-3-carboxylic acid (16205-46-2) → pyrazolo[1,5-a]pyridine-3-carbonyl chloride (78933-24-1)

Guidance literature:

With thionyl chloride;

DOI:10.1248/cpb.43.174

Reference yield: 87.0%

3-amino-p-toluic acid (2458-12-0) + pyrazolo[1,5-a]pyridine-3-carbonyl chloride (78933-24-1) → 4-methyl-3-(pyrazolo[1,5-a]pyridine-3-carboxamido)benzoic acid

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/acs.jmedchem.6b00703

Reference yield:

N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide (30069-31-9) + pyrazolo[1,5-a]pyridine-3-carbonyl chloride (78933-24-1) → pyrazolo[1,5-a]pyridine-3-carboxylic acid [2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenyl]-amide

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

pyrazolo[1,5-a]pyridine-3-carboxylic acid

Downstream raw materials:

C₁₄H₁₀FN₃O

C₁₅H₁₃N₃O₃S

C₁₅H₁₂ClN₃O

C₁₅H₁₃N₃O₂

Refernces

• 1、 Qiao, Lixin,Choi, Sungwoon,Case, April,Gainer, Thomas G.,Seyb, Kathleen,Glicksman, Marcie A.,Lo, Donald C.,Stein, Ross L.,Cuny, Gregory D.. "Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors". supporting information; experimental part. p. 6122 - 6126. Retrieved 2010/06/16.
• 2、 Miyashita,Sato,Watanabe,Tanji,Higashino. "Synthesis of 2,6-disubstituted pyridines by lithiation of pyrazolo[1,5-a] pyridines". . p. 174 - 176. Retrieved 2007/10/02.