tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate
CAS No.:158985-37-6
Molecular Formula:C16H24N2O3
Molecular Weight:292.378
Hs Code.:2933599090
DSSTox Substance ID:DTXSID10383730
Nikkaji Number:J3.472.943C
Wikidata:Q82175519
Mol file:158985-37-6.mol

Synonyms:158985-37-6;tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate;TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE;tert-butyl 4-[4-(hydroxymethyl)phenyl]piperazine-1-carboxylate;4-(1-Boc-piperazin-4-yl)phenylmethanol;MFCD06411543;tert-butyl4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[4-(hydroxymethyl)phenyl]-, 1,1-dimethylethyl ester;4-(4-N-Boc-piperazinyl)benzylalcohol;[4-(4-tert-Butoxycarbonyl)piperazine]benzyl alcohol;SCHEMBL1136833;AMY4913;DTXSID10383730;PXKYXTXYWJKTSQ-UHFFFAOYSA-N;AKOS015912221;4-(4-Boc-piperazin-1-yl)benzyl Alcohol;AS-36995;SY006211;A3512;CS-0060943;FT-0603791;4-(Piperazin-4-yl)benzyl alcohol'N1-boc protected;W-205833;1-(tert-Butoxycarbonyl)-4-(4-hydroxymethylphenyl)piperazine;1-hydroxymethyl-4-(4-(1,1-dimethylethoxycarbonyl)piperazinyl)benzene;4-[4-(Hydroxymethyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester;Dimethyl1,4-dihydro-2,6-dimethyl-1,4-diphenyl-3,5-pyridinedicarboxylate

Suppliers and Price of tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl4-(4-(Hydroxymethyl)phenyl)piperazine-1-carboxylate
100mg
$ 60.00

SynQuest Laboratories
4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzyl alcohol
1 g
$ 192.00

SynQuest Laboratories
4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzyl alcohol
250 mg
$ 72.00

American Custom Chemicals Corporation
TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE 95.00%
1G
$ 752.14

American Custom Chemicals Corporation
TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE 95.00%
250MG
$ 642.99

Ambeed
tert-Butyl4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate 95%
5g
$ 335.00

Ambeed
tert-Butyl4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate 95%
1g
$ 98.00

Ambeed
tert-Butyl4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate 95%
250mg
$ 42.00

AK Scientific
tert-Butyl4-[4-(hydroxymethyl)phenyl]tetrahydro-1(2H)-pyrazinecarboxylate
5g
$ 477.00

Acrotein
4-(1-Boc-piperazin-4-yl)phenylmethanol 97%
1g
$ 110.00

Total 18 raw suppliers

Chemical Property of tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate

Chemical Property:

Vapor Pressure:5.86E-09mmHg at 25°C
Melting Point:109 °C
Refractive Index:1.553
Boiling Point:452 °C at 760 mmHg
PKA:15.05±0.10(Predicted)
Flash Point:227.2 °C
PSA：53.01000
Density:1.152 g/cm³
LogP:2.23890
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:292.17869263
Heavy Atom Count:21
Complexity:338

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(4-(Hydroxymethyl)phenyl)piperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCN(CC1)C2=CC=C(C=C2)CO
Uses tert-Butyl 4-(4-(Hydroxymethyl)phenyl)piperazine-1-carboxylate is used as a reactant in the preparation of 4-[(4-piperazinobeznoyl)amino]phenyl(oxy)alkanoates as fibrinogen receptor antagonists.

Technology Process of tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate

There total 4 articles about tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 158985-36-5
4-(4-methoxycarbonyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 158985-37-6
1-hydroxymethyl-4-(4-(1,1-dimethylethoxycarbonyl)piperazinyl)benzene

Guidance literature:: 4-(4-methoxycarbonyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester; With diethylzinc; lithium chloride; In tetrahydrofuran; hexane; at 20 ℃; for 6h; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; hexane; water; at 20 ℃; for 8h; chemoselective reaction; Inert atmosphere;
DOI:10.1002/chem.201406176