[2-[5-[[6-[[3-(hydroxymethyl)phenyl]amino]-4-pyrimidinyl]amino]-2-methoxyphenoxy]ethyl]-carbamic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:[2-[5-[[6-[[3-(hydroxymethyl)phenyl]amino]-4-pyrimidinyl]amino]-2-methoxyphenoxy]ethyl]-carbamic acid 1,1-dimethylethyl ester
CAS No.:892413-87-5
Molecular Formula:C₂₅H₃₁N₅O₅
Molecular Weight:481.552
Hs Code.:

Synonyms:[2-[5-[[6-[[3-(hydroxymethyl)phenyl]amino]-4-pyrimidinyl]amino]-2-methoxyphenoxy]ethyl]-carbamic acid 1,1-dimethylethyl ester

Suppliers and Price of [2-[5-[[6-[[3-(hydroxymethyl)phenyl]amino]-4-pyrimidinyl]amino]-2-methoxyphenoxy]ethyl]-carbamic acid 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [2-[5-[[6-[[3-(hydroxymethyl)phenyl]amino]-4-pyrimidinyl]amino]-2-methoxyphenoxy]ethyl]-carbamic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [2-[5-[[6-[[3-(hydroxymethyl)phenyl]amino]-4-pyrimidinyl]amino]-2-methoxyphenoxy]ethyl]-carbamic acid 1,1-dimethylethyl ester

There total 1 articles about [2-[5-[[6-[[3-(hydroxymethyl)phenyl]amino]-4-pyrimidinyl]amino]-2-methoxyphenoxy]ethyl]-carbamic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 892413-86-4
3-[[6-[(3-hydroxy-4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-benzenemethanol

: 39684-80-5
2-(tert-butoxycarbonylamino)ethyl bromide

: 892413-87-5
[2-[5-[[6-[[3-(hydroxymethyl)phenyl]amino]-4-pyrimidinyl]amino]-2-methoxyphenoxy]ethyl]-carbamic acid 1,1-dimethylethyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 - 50 ℃;

Reference yield:

: 892413-87-5
[2-[5-[[6-[[3-(hydroxymethyl)phenyl]amino]-4-pyrimidinyl]amino]-2-methoxyphenoxy]ethyl]-carbamic acid 1,1-dimethylethyl ester

: 5619-07-8
methyl 2-amino-3-phenylpropanoate hydrochloride

: N-[3-[6-[[3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-4-methoxyphenyl]amino]-4-pyrimidinyl]amino]-phenylalanine methyl ester

Guidance literature:: [2-[5-[[6-[[3-(hydroxymethyl)phenyl]amino]-4-pyrimidinyl]amino]-2-methoxyphenoxy]ethyl]-carbamic acid 1,1-dimethylethyl ester; With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; at 20 ℃; for 0.25h;

methyl 2-amino-3-phenylpropanoate hydrochloride; In acetonitrile; at 65 - 80 ℃; for 28h;

In dichloromethane; acetonitrile; at 20 ℃; for 40h;

Reference yield:

: 892413-87-5
[2-[5-[[6-[[3-(hydroxymethyl)phenyl]amino]-4-pyrimidinyl]amino]-2-methoxyphenoxy]ethyl]-carbamic acid 1,1-dimethylethyl ester

: 13515-93-0
N-methylglycine methyl ester hydrochloride

: N-[[3-[[6-[[3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-4-methoxyphenyl]amino]-4-pyrimidinyl]amino]phenyl]methyl]-N-methyl-glycine methyl ester

Guidance literature:: [2-[5-[[6-[[3-(hydroxymethyl)phenyl]amino]-4-pyrimidinyl]amino]-2-methoxyphenoxy]ethyl]-carbamic acid 1,1-dimethylethyl ester; With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; at 20 ℃; for 0.25h;

N-methylglycine methyl ester hydrochloride; With polystyryl-isocyanate; In dichloromethane; acetonitrile; at 20 - 65 ℃; for 40h;