[4-(3'-cyclopropyl-4'-hydroxybenzyl)-3,5-dimethylphenoxy]methylphosphonic acid

Base Information

Chemical Name:[4-(3'-cyclopropyl-4'-hydroxybenzyl)-3,5-dimethylphenoxy]methylphosphonic acid
CAS No.:852949-76-9
Molecular Formula:C₁₉H₂₃O₅P
Molecular Weight:362.362
Hs Code.:

Synonyms:[4-(3'-cyclopropyl-4'-hydroxybenzyl)-3,5-dimethylphenoxy]methylphosphonic acid

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Chemical Property of [4-(3'-cyclopropyl-4'-hydroxybenzyl)-3,5-dimethylphenoxy]methylphosphonic acid

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Technology Process of [4-(3'-cyclopropyl-4'-hydroxybenzyl)-3,5-dimethylphenoxy]methylphosphonic acid

There total 6 articles about [4-(3'-cyclopropyl-4'-hydroxybenzyl)-3,5-dimethylphenoxy]methylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 852949-81-6
diethyl [4-(3'-cyclopropyl-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate

: 852949-76-9
[4-(3'-cyclopropyl-4'-hydroxybenzyl)-3,5-dimethylphenoxy]methylphosphonic acid

Guidance literature:: diethyl [4-(3'-cyclopropyl-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate; With trimethylsilyl bromide; In dichloromethane; at -30 - 20 ℃; for 16h;

With water; In acetonitrile; at 38 ℃; for 0.5h;

Reference yield:

: 852949-17-8
(2,6-dimethyl-4-triisopropylsilanyloxyphenyl)-(4-methoxymethoxyphenyl)methanol

: 852949-76-9
[4-(3'-cyclopropyl-4'-hydroxybenzyl)-3,5-dimethylphenoxy]methylphosphonic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium on activated charcoal / acetic acid; ethyl acetate / 5 h / 20 °C / 760.05 Torr

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; diethyl ether / 1 h / -20 - 0 °C

2.2: 2 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C

3.2: 2.5 h / 20 °C

4.1: iodine; copper / benzene / 144.17 h / 20 - 70 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 21 h / 0 - 20 °C

7.1: trimethylsilyl bromide / dichloromethane / 16 h / -30 - 20 °C

7.2: 0.5 h / 38 °C

With n-butyllithium; trimethylsilyl bromide; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; hydrogen; iodine; copper; caesium carbonate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide; benzene;

Reference yield:

: 6515-21-5
4-methoxymethoxy-benzaldehyde

: 852949-76-9
[4-(3'-cyclopropyl-4'-hydroxybenzyl)-3,5-dimethylphenoxy]methylphosphonic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: hydrogen / palladium on activated charcoal / acetic acid; ethyl acetate / 5 h / 20 °C / 760.05 Torr

3.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; diethyl ether / 1 h / -20 - 0 °C

3.2: 2 h / 0 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C

4.2: 2.5 h / 20 °C

5.1: iodine; copper / benzene / 144.17 h / 20 - 70 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

7.1: caesium carbonate / N,N-dimethyl-formamide / 21 h / 0 - 20 °C

8.1: trimethylsilyl bromide / dichloromethane / 16 h / -30 - 20 °C

8.2: 0.5 h / 38 °C

With n-butyllithium; trimethylsilyl bromide; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; hydrogen; iodine; copper; caesium carbonate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide; benzene;