3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl alcohol

Base Information

Chemical Name:3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl alcohol
CAS No.:807341-96-4
Molecular Formula:C₅₉H₉₀N₆O₁₁
Molecular Weight:1059.4
Hs Code.:

Synonyms:3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl alcohol

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Chemical Property of 3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl alcohol

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Technology Process of 3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl alcohol

There total 3 articles about 3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 210355-26-3
3,5-Bis-(3-tert-butoxycarbonylamino-propyl)-benzoic acid

: 3,5-bis(3-aminopropyl)benzyl alcohol dihydrochloride

: 807341-96-4
3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl alcohol

Guidance literature:: 3,5-Bis-(3-tert-butoxycarbonylamino-propyl)-benzoic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at -30 ℃; for 3h;

3,5-bis(3-aminopropyl)benzyl alcohol dihydrochloride; With triethylamine; In methanol; dichloromethane; at 20 ℃; for 14h; Further stages.;
DOI:10.1002/chem.200305142

Reference yield:

: 67973-33-5
3,5-dibromobenzoic acid ethyl ester

: 807341-96-4
3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl alcohol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 9-borabicyclo[3.3.1]nonane / toluene / 12 h / 0 °C

1.2: KOH / [Pd(PPh₃)4] / toluene / 10 h / 100 °C

2.1: 92 percent / KOH / 10 h / 55 °C

3.1: HOBt; EDC / CH₂Cl₂ / 3 h / -30 °C

3.2: 65 percent / Et₃N / methanol; CH₂Cl₂ / 14 h / 20 °C

With potassium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 9-bora-bicyclo[3.3.1]nonane; In dichloromethane; toluene;
DOI:10.1002/chem.200305142

Reference yield:

: 210355-25-2
3,5-Bis-(3-tert-butoxycarbonylamino-propyl)-benzoic acid ethyl ester

: 807341-96-4
3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / KOH / 10 h / 55 °C

2.1: HOBt; EDC / CH₂Cl₂ / 3 h / -30 °C

2.2: 65 percent / Et₃N / methanol; CH₂Cl₂ / 14 h / 20 °C

With potassium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1002/chem.200305142