3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl methacrylate

Base Information

Chemical Name:3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl methacrylate
CAS No.:700865-55-0
Molecular Formula:C₆₃H₉₄N₆O₁₂
Molecular Weight:1127.47
Hs Code.:

Synonyms:3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl methacrylate

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Chemical Property of 3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl methacrylate

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Technology Process of 3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl methacrylate

There total 4 articles about 3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl methacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 920-46-7,26937-45-1
Methacryloyl chloride

: 807341-96-4
3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl alcohol

: 700865-55-0
3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl methacrylate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1002/chem.200305142

Reference yield:

: 67973-33-5
3,5-dibromobenzoic acid ethyl ester

: 700865-55-0
3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl methacrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 9-borabicyclo[3.3.1]nonane / toluene / 12 h / 0 °C

1.2: KOH / [Pd(PPh₃)4] / toluene / 10 h / 100 °C

2.1: 92 percent / KOH / 10 h / 55 °C

3.1: HOBt; EDC / CH₂Cl₂ / 3 h / -30 °C

3.2: 65 percent / Et₃N / methanol; CH₂Cl₂ / 14 h / 20 °C

4.1: 96 percent / DMAP; eT₃n / tetrahydrofuran / 12 h / 20 °C

With dmap; potassium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/chem.200305142

Reference yield:

: 210355-25-2
3,5-Bis-(3-tert-butoxycarbonylamino-propyl)-benzoic acid ethyl ester

: 700865-55-0
3,5-[bis(3-{3,5-bis[3-(tert-butyloxycarbonylamino)propyl]benzoyl}amino)propyl]benzyl methacrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / KOH / 10 h / 55 °C

2.1: HOBt; EDC / CH₂Cl₂ / 3 h / -30 °C

2.2: 65 percent / Et₃N / methanol; CH₂Cl₂ / 14 h / 20 °C

3.1: 96 percent / DMAP; eT₃n / tetrahydrofuran / 12 h / 20 °C

With dmap; potassium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.200305142