(11aR)-(+)-11a-allyl-10-di(p-anisyl)methyl-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

Base Information

Chemical Name:(11aR)-(+)-11a-allyl-10-di(p-anisyl)methyl-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine
CAS No.:918160-21-1
Molecular Formula:C₃₀H₃₀N₂O₄
Molecular Weight:482.579
Hs Code.:

Synonyms:(11aR)-(+)-11a-allyl-10-di(p-anisyl)methyl-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

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Chemical Property of (11aR)-(+)-11a-allyl-10-di(p-anisyl)methyl-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

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Technology Process of (11aR)-(+)-11a-allyl-10-di(p-anisyl)methyl-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

There total 3 articles about (11aR)-(+)-11a-allyl-10-di(p-anisyl)methyl-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918160-14-2
(11aS)-(+)-10-di(p-anisyl)methyl-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

: 106-95-6
allyl bromide

: 918160-21-1
(11aR)-(+)-11a-allyl-10-di(p-anisyl)methyl-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

: (11aS)-11a-allyl-10-di(p-anisyl)methyl-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

Guidance literature:: (11aS)-(+)-10-di(p-anisyl)methyl-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine; allyl bromide; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; at -100 ℃; for 0.25h;

With potassium hexamethylsilazane; In tetrahydrofuran; hexane; at -100 ℃; Title compound not separated from byproducts;
DOI:10.1021/ja0640142

Reference yield:

: 69545-37-5
di(p-anisyl)methyl bromide

: 918160-21-1
(11aR)-(+)-11a-allyl-10-di(p-anisyl)methyl-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / NaH / tetrahydrofuran; various solvent(s) / 0 °C

2.1: HMPA / tetrahydrofuran / 0.25 h / -100 °C

2.2: KHMDS / tetrahydrofuran; hexane / -100 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ja0640142

Reference yield:

: 728-87-0
4,4'-Dimethoxybenzhydrol

: 918160-21-1
(11aR)-(+)-11a-allyl-10-di(p-anisyl)methyl-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / acetyl bromide / benzene / 1 h / 20 °C

2.1: 93 percent / NaH / tetrahydrofuran; various solvent(s) / 0 °C

3.1: HMPA / tetrahydrofuran / 0.25 h / -100 °C

3.2: KHMDS / tetrahydrofuran; hexane / -100 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; Acetyl bromide; sodium hydride; In tetrahydrofuran; benzene;
DOI:10.1021/ja0640142