2-AMINO-3,6-DICHLOROBENZOIC ACID

Base Information

• Chemical Name: 2-AMINO-3,6-DICHLOROBENZOIC ACID
• CAS No.: 3032-32-4
• Molecular Formula: C7H5 Cl2 N O2
• Molecular Weight: 206.028
• Hs Code.: 29224999
• Mol file: 3032-32-4.mol

Synonyms:Anthranilicacid, 3,6-dichloro- (6CI,7CI,8CI); 2-Amino-3,6-dichlorobenzoic acid;3,6-Dichloroanthranilic acid

Chemical Property of 2-AMINO-3,6-DICHLOROBENZOIC ACID

Chemical Property:

• Appearance/Colour: slight yellow crystalline powder
• Vapor Pressure: 3.54E-05mmHg at 25°C
• Melting Point: 150-154°C
• Refractive Index: 1.6100 (estimate)
• Boiling Point: 339.6°Cat760mmHg
• PKA: 3.25±0.25(Predicted)
• Flash Point: 159.2°C
• PSA: 63.32000
• Density: 1.607g/cm³
• LogP: 2.85500
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Chloroform, DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Insoluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-3,6-dichlorobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-3,6-dichlorobenzoic acid is used as a pharmaceutical intermediate and also finds use in chemical research.

Technology Process of 2-AMINO-3,6-DICHLOROBENZOIC ACID

There total 14 articles about 2-AMINO-3,6-DICHLOROBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

→ 2-amino-3,6-dichlorobenzyl alcohol (58579-67-2) + 3,6-dichloroanthranilic acid (3032-32-4)

Guidance literature:

Reference yield: 67.0%

4,7-dichloroisatin (18711-13-2) → 3,6-dichloroanthranilic acid (3032-32-4)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In water; at 50 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol401375n

Reference yield:

2,5 dichloroaniline (95-82-9) → 3,6-dichloroanthranilic acid (3032-32-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium sulfate / water; ethanol / 12 h / 80 °C / Inert atmosphere; Schlenk technique

2: sulfuric acid / water / 0.25 h / 100 °C / Inert atmosphere; Schlenk technique

3: sodium hydroxide; dihydrogen peroxide / water / 0.5 h / 50 °C / Inert atmosphere; Schlenk technique

With sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; sodium sulfate; sodium hydroxide; In ethanol; water;

DOI:10.1021/ol401375n

upstream raw materials:

4,7-dichloroisatin

2-azido-3,6-dichloro-benzaldehyde

5,8-dichloro-3-(2,5-dichloro-phenyl)-1H-quinazoline-2,4-dione

4,7-dichloro-benzo[c]isoxazole

Downstream raw materials:

1-(2-Amino-3,6-dichloro-phenyl)-ethanone

2,5-dichlorobenzoic acid

2-Amino-3,6-dichloro-N-methoxy-N-methyl-benzamide

2,5-dichloroacetanilide

Refernces

• 1、 Chang, Ning-Hui,Chen, Xi-Chao,Nonobe, Hikaru,Okuda, Yasuhiro,Mori, Hiroki,Nakajima, Kiyohiko,Nishihara, Yasushi. "Synthesis of substituted picenes through Pd-catalyzed cross-coupling reaction/annulation sequences and their physicochemical properties". supporting information. p. 3558 - 3561. Retrieved 2013/08/23.
• 2、 -. "Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones". . . Retrieved 2008/06/13.