methyl 4-amino-2,6-dichloro-3-((trimethylsilyl)ethynyl)benzoate

Base Information

Chemical Name:methyl 4-amino-2,6-dichloro-3-((trimethylsilyl)ethynyl)benzoate
CAS No.:1613730-12-3
Molecular Formula:C₁₃H₁₅Cl₂NO₂Si
Molecular Weight:316.259
Hs Code.:

Synonyms:methyl 4-amino-2,6-dichloro-3-((trimethylsilyl)ethynyl)benzoate

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Chemical Property of methyl 4-amino-2,6-dichloro-3-((trimethylsilyl)ethynyl)benzoate

Chemical Property:

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Technology Process of methyl 4-amino-2,6-dichloro-3-((trimethylsilyl)ethynyl)benzoate

There total 5 articles about methyl 4-amino-2,6-dichloro-3-((trimethylsilyl)ethynyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7149-69-1
1,3-dichloro-2-methyl-5-nitrobenzene

: 1613730-12-3
methyl 4-amino-2,6-dichloro-3-((trimethylsilyl)ethynyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium permanganate / water; pyridine / 20 °C / Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 2 h

3.1: tin(II) chloride dihdyrate / N,N-dimethyl-formamide / 0.67 h / 100 °C / Microwave irradiation

4.1: iodine; silver sulfate / ethanol / 0.25 h / Inert atmosphere

5.1: copper(l) iodide; triphenylphosphine; triethylamine; bis-triphenylphosphine-palladium(II) chloride / toluene / 1.5 h / 60 - 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium permanganate; copper(l) iodide; tin(II) chloride dihdyrate; iodine; caesium carbonate; silver sulfate; triethylamine; triphenylphosphine; In pyridine; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1613730-11-2
methyl 4-amino-2,6-dichloro-3-iodobenzoate

: 1066-54-2
trimethylsilylacetylene

: 1613730-12-3
methyl 4-amino-2,6-dichloro-3-((trimethylsilyl)ethynyl)benzoate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; In toluene; at 60 - 70 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 22509-50-8
2,6-dichloro-4-nitrobenzoic acid

: 1613730-12-3
methyl 4-amino-2,6-dichloro-3-((trimethylsilyl)ethynyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 2 h

2.1: tin(II) chloride dihdyrate / N,N-dimethyl-formamide / 0.67 h / 100 °C / Microwave irradiation

3.1: iodine; silver sulfate / ethanol / 0.25 h / Inert atmosphere

4.1: copper(l) iodide; triphenylphosphine; triethylamine; bis-triphenylphosphine-palladium(II) chloride / toluene / 1.5 h / 60 - 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tin(II) chloride dihdyrate; iodine; caesium carbonate; silver sulfate; triethylamine; triphenylphosphine; In ethanol; N,N-dimethyl-formamide; toluene;