4-chloro-1-naphthalenesulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine]-ethoxy}-benzofuran-5-yl}-amide hydrochloride

Base Information

Chemical Name:4-chloro-1-naphthalenesulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine]-ethoxy}-benzofuran-5-yl}-amide hydrochloride
CAS No.:1089187-48-3
Molecular Formula:C₃₄H₃₅ClF₃N₃O₅S*ClH
Molecular Weight:726.644
Hs Code.:

4-chloro-1-naphthalenesulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine]-ethoxy}-benzofuran-5-yl}-amide hydrochloride

Synonyms:4-chloro-1-naphthalenesulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine]-ethoxy}-benzofuran-5-yl}-amide hydrochloride

Suppliers and Price of 4-chloro-1-naphthalenesulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine]-ethoxy}-benzofuran-5-yl}-amide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-chloro-1-naphthalenesulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine]-ethoxy}-benzofuran-5-yl}-amide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-chloro-1-naphthalenesulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine]-ethoxy}-benzofuran-5-yl}-amide hydrochloride

There total 4 articles about 4-chloro-1-naphthalenesulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine]-ethoxy}-benzofuran-5-yl}-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1089187-35-8
2,2-dimethyl-5-amino-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazin-1-yl]-ethoxy}-2,3-dihydro-benzofuran

: 64318-08-7
4-chloro-1-naphthalenesulfonyl chloride

: 1089187-48-3
4-chloro-1-naphthalenesulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine]-ethoxy}-benzofuran-5-yl}-amide hydrochloride

Guidance literature:: 2,2-dimethyl-5-amino-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazin-1-yl]-ethoxy}-2,3-dihydro-benzofuran; 4-chloro-1-naphthalenesulfonyl chloride; With pyridine; In dichloromethane; at 20 ℃; for 48h;

With hydrogenchloride; In water;

Reference yield:

: 1089187-62-1
2,2-dimethyl-5-nitro-7-(2-chloro-ethoxy)-2,3-dihydro-benzofuran

: 1089187-48-3
4-chloro-1-naphthalenesulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine]-ethoxy}-benzofuran-5-yl}-amide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water / 8.5 h / Heating / reflux

2: hydrazine / 5%-palladium/activated carbon / ethanol / 2 h / Heating / reflux

3: pyridine / dichloromethane / 48 h / 20 °C

With pyridine; sodium hydroxide; hydrazine; 5%-palladium/activated carbon; In ethanol; dichloromethane; water;

Reference yield:

: 113194-07-3
2,2-dimethyl-5-nitro-2,3-dihydro-benzofuran-7-ol

: 1089187-48-3
4-chloro-1-naphthalenesulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine]-ethoxy}-benzofuran-5-yl}-amide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 5 h / Heating / reflux

2: sodium hydroxide / water / 8.5 h / Heating / reflux

3: hydrazine / 5%-palladium/activated carbon / ethanol / 2 h / Heating / reflux

4: pyridine / dichloromethane / 48 h / 20 °C

With pyridine; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; hydrazine; 5%-palladium/activated carbon; In ethanol; dichloromethane; water;