[1-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-meth-(E)-ylidene]-[2-(2-fluoro-phenyl)-ethyl]-amine

Base Information

Chemical Name:[1-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-meth-(E)-ylidene]-[2-(2-fluoro-phenyl)-ethyl]-amine
CAS No.:610312-12-4
Molecular Formula:C₂₃H₂₆FNO₄
Molecular Weight:399.462
Hs Code.:

Synonyms:[1-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-meth-(E)-ylidene]-[2-(2-fluoro-phenyl)-ethyl]-amine

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Chemical Property of [1-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-meth-(E)-ylidene]-[2-(2-fluoro-phenyl)-ethyl]-amine

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Technology Process of [1-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-meth-(E)-ylidene]-[2-(2-fluoro-phenyl)-ethyl]-amine

There total 5 articles about [1-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-meth-(E)-ylidene]-[2-(2-fluoro-phenyl)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23558-05-6
3-O-benzyl-1,2-O-isopropylidene-1,5-D-xylo-dialdofuranose

: 52721-69-4
[2-(2-fluorophenyl)ethyl]amine

: 610312-12-4
[1-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-meth-(E)-ylidene]-[2-(2-fluoro-phenyl)-ethyl]-amine

Guidance literature:: With sodium sulfate; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1081/SCC-120017195

Reference yield:

: 22529-61-9
(1R)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro(2,3-d)(1,3)dioxol-5-yl)ethane-1,2-diol

: 610312-12-4
[1-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-meth-(E)-ylidene]-[2-(2-fluoro-phenyl)-ethyl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: NaIO₄; aq. NaHCO₃ / CH₂Cl₂ / 2 h / 20 °C

2: sodium sulphate / CH₂Cl₂ / 1 h / 20 °C

With sodium periodate; sodium hydrogencarbonate; sodium sulfate; In dichloromethane;
DOI:10.1081/SCC-120017195

Reference yield:

: 100-39-0
benzyl bromide

: 610312-12-4
[1-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-meth-(E)-ylidene]-[2-(2-fluoro-phenyl)-ethyl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.25 h / 0 °C

1.2: 94 percent / dimethylformamide / 0.5 h / 0 °C

2.1: 87 percent / aq. H₂SO₄ / methanol / 12 h

3.1: NaIO₄; aq. NaHCO₃ / CH₂Cl₂ / 2 h / 20 °C

4.1: sodium sulphate / CH₂Cl₂ / 1 h / 20 °C

With sodium periodate; sulfuric acid; sodium hydride; sodium hydrogencarbonate; sodium sulfate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1081/SCC-120017195