2-methoxy-2-(1-phenyl-1-hydroxyethyl)-6-methyltetrahydropyran

Base Information

• Chemical Name: 2-methoxy-2-(1-phenyl-1-hydroxyethyl)-6-methyltetrahydropyran
• CAS No.: 75993-77-0
• Molecular Formula: C₁₅H₂₂O₃
• Molecular Weight: 250.338
• Mol file: 75993-77-0.mol

Synonyms:2-methoxy-2-(1-phenyl-1-hydroxyethyl)-6-methyltetrahydropyran

Chemical Property of 2-methoxy-2-(1-phenyl-1-hydroxyethyl)-6-methyltetrahydropyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-2-(1-phenyl-1-hydroxyethyl)-6-methyltetrahydropyran

There total 3 articles about 2-methoxy-2-(1-phenyl-1-hydroxyethyl)-6-methyltetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

cis-2-methoxy-6-methyltetrahydropyran (76024-08-3,17230-07-8,17230-08-9,18653-59-3,58801-51-7,58801-54-0,76024-09-4,76024-10-7,76024-11-8) + acetophenone (98-86-2) → methyl hexanoate (106-70-7) + 2,3-diphenyl-2,3-butanediol (1636-34-6) + 1,7-dimethyl-7-phenyl-6,8-dioxobicyclo<3.2.1>octane (75993-78-1) + 2-methoxy-2-(1-phenyl-1-hydroxyethyl)-6-methyltetrahydropyran (75993-77-0)

Guidance literature:

In benzene; for 20h; Further byproducts given; Irradiation; or from cis-isomer;

DOI:10.1021/jo00317a017

Reference yield: 8.5%

cis-2-methoxy-6-methyltetrahydropyran (76024-08-3,17230-07-8,17230-08-9,18653-59-3,58801-51-7,58801-54-0,76024-09-4,76024-10-7,76024-11-8) + acetophenone (98-86-2) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → methyl hexanoate (106-70-7) + 2,3-diphenyl-2,3-butanediol (1636-34-6) + methyl 5-phenylhexanoate (13317-80-1) + 2-methoxy-2-(1-phenyl-1-hydroxyethyl)-6-methyltetrahydropyran (75993-77-0) + trans-2-methoxy-6-methyltetrahydropyran (76024-10-7,17230-07-8,17230-08-9,18653-59-3,58801-51-7,58801-54-0,76024-08-3,76024-09-4,76024-11-8) + 5-hexanolide (823-22-3,26991-67-3)

Guidance literature:

for 20h; Product distribution; Mechanism; Irradiation; investigation of reactions of 2-methoxy-6-methyltetrahydropyrans;

DOI:10.1021/jo00317a017

Reference yield:

3,4-dihydro-2-methoxy-6-methyl-2H-pyran (28194-35-6) → 2-methoxy-2-(1-phenyl-1-hydroxyethyl)-6-methyltetrahydropyran (75993-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / H₂ / Raney nickel / diethyl ether / 48 h / 93086.7 Torr

2: 7 percent / benzene / 20 h / Irradiation; or from cis-isomer

With hydrogen; nickel; In diethyl ether; benzene;

DOI:10.1021/jo00317a017

upstream raw materials:

cis-2-methoxy-6-methyltetrahydropyran

acetophenone

benzene

3,4-dihydro-2-methoxy-6-methyl-2H-pyran