(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide

Base Information

Chemical Name:(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide
CAS No.:1542267-11-7
Molecular Formula:C₂₂H₂₄FN₇O₃
Molecular Weight:453.476
Hs Code.:

Synonyms:(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide

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Chemical Property of (S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide

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Technology Process of (S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide

There total 7 articles about (S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1542268-17-6
C₂₄H₂₆FN₇O₄

: 1542267-11-7
(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide

Guidance literature:: With acetic acid; zinc; In methanol; at 80 ℃; for 14h;

Reference yield:

: 94193-79-0
2-chloro-N-((S)-2-hydroxy-1-methylethyl)acetamide

: 1542267-11-7
(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / dichloromethane; isopropyl alcohol / 0 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C

4: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 4 h / 60 °C

5: zinc; acetic acid / methanol / 14 h / 80 °C

With lithium aluminium tetrahydride; 18-crown-6 ether; potassium tert-butylate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 1542267-11-7
(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C

2: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 4 h / 60 °C

3: zinc; acetic acid / methanol / 14 h / 80 °C

With 18-crown-6 ether; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;