(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

Base Information

Chemical Name:(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride
CAS No.:1542268-12-1
Molecular Formula:C₂₂H₂₄FN₇O₃*ClH
Molecular Weight:489.937
Hs Code.:

Synonyms:(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

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Chemical Property of (S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

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Technology Process of (S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

There total 8 articles about (S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1542267-11-7
(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide

: 1542268-12-1
(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; at 20 ℃; for 0.5h;

Reference yield:

: 94193-79-0
2-chloro-N-((S)-2-hydroxy-1-methylethyl)acetamide

: 1542268-12-1
(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: potassium tert-butylate / dichloromethane; isopropyl alcohol / 0 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C

4: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 4 h / 60 °C

5: zinc; acetic acid / methanol / 14 h / 80 °C

6: hydrogenchloride / diethyl ether / 0.5 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; 18-crown-6 ether; potassium tert-butylate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 1542268-12-1
(S)-4-((4-(6-aminopyridin-3-yl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)oxy)-3-fluoro-N,N-dimethylbenzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C

2: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 4 h / 60 °C

3: zinc; acetic acid / methanol / 14 h / 80 °C

4: hydrogenchloride / diethyl ether / 0.5 h / 20 °C

With hydrogenchloride; 18-crown-6 ether; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;