2-[2-methoxy-5-nitro-4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenoxy]-N-(2-(N-tert-butoxycarbonylamino)ethylamine)acetamide

Base Information

Chemical Name:2-[2-methoxy-5-nitro-4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenoxy]-N-(2-(N-tert-butoxycarbonylamino)ethylamine)acetamide
CAS No.:1227683-26-2
Molecular Formula:C₂₄H₂₈N₄O₁₂
Molecular Weight:564.506
Hs Code.:

Synonyms:2-[2-methoxy-5-nitro-4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenoxy]-N-(2-(N-tert-butoxycarbonylamino)ethylamine)acetamide

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Chemical Property of 2-[2-methoxy-5-nitro-4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenoxy]-N-(2-(N-tert-butoxycarbonylamino)ethylamine)acetamide

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Technology Process of 2-[2-methoxy-5-nitro-4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenoxy]-N-(2-(N-tert-butoxycarbonylamino)ethylamine)acetamide

There total 1 articles about 2-[2-methoxy-5-nitro-4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenoxy]-N-(2-(N-tert-butoxycarbonylamino)ethylamine)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227683-22-8
2-(4-hydroxymethyl-2-methoxy-5-nitrophenoxy)-N-(2-(N-tert-butoxycarbonylamino)ethylamine)acetamide

: 7693-46-1
4-Nitrophenyl chloroformate

: 1227683-26-2
2-[2-methoxy-5-nitro-4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenoxy]-N-(2-(N-tert-butoxycarbonylamino)ethylamine)acetamide

Guidance literature:: 2-(4-hydroxymethyl-2-methoxy-5-nitrophenoxy)-N-(2-(N-tert-butoxycarbonylamino)ethylamine)acetamide; 4-Nitrophenyl chloroformate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; at 20 ℃; for 12h;

With dmap; In tetrahydrofuran; chloroform; at 20 ℃; for 4h;
DOI:10.1039/b927215c

Reference yield: 72.0%

: 1227683-26-2
2-[2-methoxy-5-nitro-4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenoxy]-N-(2-(N-tert-butoxycarbonylamino)ethylamine)acetamide

: 25316-40-9
doxorubicin hydrochloride

: 1227683-23-9
C₄₅H₅₂N₄O₂₀

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 36h; Darkness;
DOI:10.1039/b927215c

Reference yield:

: 1227683-26-2
2-[2-methoxy-5-nitro-4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenoxy]-N-(2-(N-tert-butoxycarbonylamino)ethylamine)acetamide

: C₃₄H₃₇FN₆O₁₃

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 18 h / 20 °C / Darkness

2: dichloromethane / 0.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / methanol / 6 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1039/c6cc05179k