Methyl N-{4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)-benzoyl}glycinate

Base Information

Chemical Name:Methyl N-{4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)-benzoyl}glycinate
CAS No.:1303518-31-1
Molecular Formula:C₂₂H₁₅Cl₃F₆N₂O₃
Molecular Weight:575.722
Hs Code.:

Synonyms:Methyl N-{4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)-benzoyl}glycinate

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Chemical Property of Methyl N-{4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)-benzoyl}glycinate

Chemical Property:

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Technology Process of Methyl N-{4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)-benzoyl}glycinate

There total 9 articles about Methyl N-{4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)-benzoyl}glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1303518-45-7
4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoic acid

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 1303518-31-1
Methyl N-{4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)-benzoyl}glycinate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1303518-35-5
4-dibromomethyl-3-trifluoromethyl-benzoic acid

: 1303518-31-1
Methyl N-{4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)-benzoyl}glycinate

Guidance literature:: Multi-step reaction with 9 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

2: silver nitrate / ethanol; water / 2 h / Reflux

3: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 20 °C

4: methanesulfonyl chloride / 1,2-dichloro-ethane / 5.33 h / Cooling with ice; Reflux

5: Lawessons reagent / toluene / 1 h / 85 °C

6: potassium tert-butylate / tetrahydrofuran / 0.5 h / -60 °C

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 20.5 h / -5 - 20 °C / Inert atmosphere

8: sulfuric acid; acetic acid / water / 26 h / Reflux

9: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C

With Lawessons reagent; sulfuric acid; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium acetate; silver nitrate; acetic acid; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1303518-36-6
4-(dibromomethyl)-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide

: 1303518-31-1
Methyl N-{4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)-benzoyl}glycinate

Guidance literature:: Multi-step reaction with 8 steps

1: silver nitrate / ethanol; water / 2 h / Reflux

2: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 20 °C

3: methanesulfonyl chloride / 1,2-dichloro-ethane / 5.33 h / Cooling with ice; Reflux

4: Lawessons reagent / toluene / 1 h / 85 °C

5: potassium tert-butylate / tetrahydrofuran / 0.5 h / -60 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 20.5 h / -5 - 20 °C / Inert atmosphere

7: sulfuric acid; acetic acid / water / 26 h / Reflux

8: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C

With Lawessons reagent; sulfuric acid; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium acetate; silver nitrate; acetic acid; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;