4'-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

Base Information

Chemical Name:4'-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid
CAS No.:1073549-10-6
Molecular Formula:C₂₈H₃₄FN₃O₄S
Molecular Weight:527.66
Hs Code.:

Synonyms:4'-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

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Chemical Property of 4'-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

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Technology Process of 4'-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

There total 15 articles about 4'-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1073549-12-8
4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

: 1073549-10-6
4'-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

Guidance literature:: 4'-{5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethyl-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid; With sodium methylate; D,L-dithiothreitol; In methanol; at 0 ℃; Inert atmosphere;

With acetic acid; In methanol; at 0 ℃;

Reference yield:

: 1073549-13-9
4'-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid hydrochloride

: 1073549-10-6
4'-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

Guidance literature:: 4'-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid hydrochloride; With sodium hydroxide; In methanol; water; pH=2;

With hydrogenchloride; In methanol; water; pH=4.2; Isoelectric point;

Reference yield:

: 88-65-3
2-bromobenzoic-acid

: 1073549-10-6
4'-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]-imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 16.17 h / 0 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / isopropyl alcohol; water / 46 h / 90 °C / Inert atmosphere

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 7 h / 90 °C / Inert atmosphere

4.1: sodium hydroxide / tetrabutylammomium bromide / toluene; water / 27 °C

5.1: caesium carbonate / palladium diacetate; catacxium A / toluene; water / 16 h / 90 °C / Inert atmosphere

6.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 24 h / 40 °C

7.1: hydrogen; ammonium hydroxide / Raney nickel / ethanol / 3 h / 760.05 Torr

8.1: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / dichloromethane / -2 - 3 °C

9.1: trifluoroacetic acid / dichloromethane / 16 h / 15 - 20 °C

10.1: sodium methylate; DL-dithiothreitol; methanol / 0.5 h / 0 °C / Inert atmosphere

10.2: 0 °C

With methanol; dmap; ammonium hydroxide; N-Bromosuccinimide; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); DL-dithiothreitol; hydroxylamine hydrochloride; hydrogen; sodium methylate; sodium hydrogencarbonate; sodium carbonate; caesium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium hydroxide; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; palladium diacetate; catacxium A; In tetrachloromethane; ethanol; dichloromethane; water; isopropyl alcohol; toluene;