5'-O-(4,4'-Dimethoxytrityl)-N⁴-(9-fluorenylmethoxycarbonyl)-2'-deoxycytidine 3'-O-<2-cyanoethyl-N,N-diisopropylphosphoramidite>

Base Information

• Chemical Name: 5'-O-(4,4'-Dimethoxytrityl)-N⁴-(9-fluorenylmethoxycarbonyl)-2'-deoxycytidine 3'-O-<2-cyanoethyl-N,N-diisopropylphosphoramidite>
• CAS No.: 109389-33-5
• Molecular Formula: C₅₄H₅₈N₅O₉P
• Molecular Weight: 952.056

Synonyms:5'-O-(4,4'-Dimethoxytrityl)-N⁴-(9-fluorenylmethoxycarbonyl)-2'-deoxycytidine 3'-O-<2-cyanoethyl-N,N-diisopropylphosphoramidite>

Chemical Property of 5'-O-(4,4'-Dimethoxytrityl)-N⁴-(9-fluorenylmethoxycarbonyl)-2'-deoxycytidine 3'-O-<2-cyanoethyl-N,N-diisopropylphosphoramidite>

Chemical Property:

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Technology Process of 5'-O-(4,4'-Dimethoxytrityl)-N⁴-(9-fluorenylmethoxycarbonyl)-2'-deoxycytidine 3'-O-<2-cyanoethyl-N,N-diisopropylphosphoramidite>

There total 5 articles about 5'-O-(4,4'-Dimethoxytrityl)-N⁴-(9-fluorenylmethoxycarbonyl)-2'-deoxycytidine 3'-O-<2-cyanoethyl-N,N-diisopropylphosphoramidite> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 5'-O-(4,4'-dimethoxytrityl)-N4-(9-fluorenylmethoxycarbonyl)-2'-deoxycytidine (109420-85-1) → 5'-O-(4,4'-Dimethoxytrityl)-N4-(9-fluorenylmethoxycarbonyl)-2'-deoxycytidine 3'-O-<2-cyanoethyl-N,N-diisopropylphosphoramidite> (109389-33-5)

Guidance literature:

With 1H-tetrazole; In dichloromethane;

DOI:10.1016/S0040-4039(00)92178-6

Reference yield:

N-Fmoc-dC (87424-19-9) → 5'-O-(4,4'-Dimethoxytrityl)-N4-(9-fluorenylmethoxycarbonyl)-2'-deoxycytidine 3'-O-<2-cyanoethyl-N,N-diisopropylphosphoramidite> (109389-33-5)

Guidance literature:

1: Substitution / 2: Substitution;

DOI:10.1080/07328319908044667

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-O-(4,4'-Dimethoxytrityl)-N4-(9-fluorenylmethoxycarbonyl)-2'-deoxycytidine 3'-O-<2-cyanoethyl-N,N-diisopropylphosphoramidite> (109389-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Ambient temperature

2: diisopropylethylammonium 1H-tetrazolide / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; N,N-diisopropylethylammonium tetrazolide; In dichloromethane;

DOI:10.1021/jo00082a011

upstream raw materials:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

5'-O-(4,4'-dimethoxytrityl)-N⁴-(9-fluorenylmethoxycarbonyl)-2'-deoxycytidine

N-Fmoc-dC

2'-Deoxycytidine

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