3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid

Base Information

Chemical Name:3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid
CAS No.:1374515-89-5
Molecular Formula:C₂₃H₁₉F₃O₃
Molecular Weight:400.397
Hs Code.:

Synonyms:3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid

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Chemical Property of 3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid

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Technology Process of 3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid

There total 4 articles about 3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1374516-18-3
C₂₄H₂₁F₃O₃

: 1374515-89-5
3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm300215x

Reference yield:

: 5597-50-2
3-(4-hydroxyphenyl)propionic acid methyl ester

: 1374515-89-5
3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 20 h / 75 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; potassium iodide; lithium hydroxide; In tetrahydrofuran; water; acetone; acetonitrile; 2: Suzuki coupling;
DOI:10.1021/jm300215x

Reference yield:

: 1236109-77-5
methyl 3-(4-((2-iodobenzyl)oxy)phenyl)propanoate

: 1374515-89-5
3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 20 h / 75 °C / Inert atmosphere

2: water; lithium hydroxide / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; water; acetonitrile; 1: Suzuki coupling;
DOI:10.1021/jm300215x