5'-(2-bromobenzylidene)-2-oxo-spiro[1-ethyl-5,6,7-trimethoxyindole-3,2'-(2',5'-dihydrofuran)]

Base Information

Chemical Name:5'-(2-bromobenzylidene)-2-oxo-spiro[1-ethyl-5,6,7-trimethoxyindole-3,2'-(2',5'-dihydrofuran)]
CAS No.:1608104-61-5
Molecular Formula:C₂₃H₂₂BrNO₅
Molecular Weight:472.335
Hs Code.:

Synonyms:5'-(2-bromobenzylidene)-2-oxo-spiro[1-ethyl-5,6,7-trimethoxyindole-3,2'-(2',5'-dihydrofuran)]

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Chemical Property of 5'-(2-bromobenzylidene)-2-oxo-spiro[1-ethyl-5,6,7-trimethoxyindole-3,2'-(2',5'-dihydrofuran)]

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Technology Process of 5'-(2-bromobenzylidene)-2-oxo-spiro[1-ethyl-5,6,7-trimethoxyindole-3,2'-(2',5'-dihydrofuran)]

There total 5 articles about 5'-(2-bromobenzylidene)-2-oxo-spiro[1-ethyl-5,6,7-trimethoxyindole-3,2'-(2',5'-dihydrofuran)] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1608112-47-5
5-[(2-bromophenyl)-hydroxy-methyl]-furan-2-carboxylic acid ethyl-(3,4,5-trimethoxyphenyl)amide

: 1608104-61-5
5'-(2-bromobenzylidene)-2-oxo-spiro[1-ethyl-5,6,7-trimethoxyindole-3,2'-(2',5'-dihydrofuran)]

Guidance literature:: With copper(ll) sulfate pentahydrate; acetic acid; In toluene; at 100 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201301238

Reference yield:

: 163629-15-0
N-ethyl-3,4,5-trimethoxyaniline

: 1608104-61-5
5'-(2-bromobenzylidene)-2-oxo-spiro[1-ethyl-5,6,7-trimethoxyindole-3,2'-(2',5'-dihydrofuran)]

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / Inert atmosphere

2: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere

3: copper(ll) sulfate pentahydrate; acetic acid / toluene / 100 °C / Inert atmosphere

With sodium tetrahydroborate; copper(ll) sulfate pentahydrate; acetic acid; triethylamine; In methanol; toluene; 3: |Friedel-Crafts Alkylation;
DOI:10.1002/ejoc.201301238

Reference yield:

: C₁₂H₆BrClO₃

: 1608104-61-5
5'-(2-bromobenzylidene)-2-oxo-spiro[1-ethyl-5,6,7-trimethoxyindole-3,2'-(2',5'-dihydrofuran)]

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / Inert atmosphere

2: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere

3: copper(ll) sulfate pentahydrate; acetic acid / toluene / 100 °C / Inert atmosphere

With sodium tetrahydroborate; copper(ll) sulfate pentahydrate; acetic acid; triethylamine; In methanol; toluene; 3: |Friedel-Crafts Alkylation;
DOI:10.1002/ejoc.201301238