N-(5-((4-(4,5-dihydro-1H-imidazol-2-yl)-2-nitrophenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

Base Information

Chemical Name:N-(5-((4-(4,5-dihydro-1H-imidazol-2-yl)-2-nitrophenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide
CAS No.:1430728-82-7
Molecular Formula:C₂₃H₁₉F₂N₅O₃
Molecular Weight:451.432
Hs Code.:

Synonyms:N-(5-((4-(4,5-dihydro-1H-imidazol-2-yl)-2-nitrophenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

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Chemical Property of N-(5-((4-(4,5-dihydro-1H-imidazol-2-yl)-2-nitrophenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

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Technology Process of N-(5-((4-(4,5-dihydro-1H-imidazol-2-yl)-2-nitrophenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

There total 9 articles about N-(5-((4-(4,5-dihydro-1H-imidazol-2-yl)-2-nitrophenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1430727-63-1
N-(2',4'-difluoro-5-(4-formyl-2-nitrophenylamino)biphenyl-3-yl)acetamide

: 107-15-3,85404-18-8
ethylenediamine

: 1430728-82-7
N-(5-((4-(4,5-dihydro-1H-imidazol-2-yl)-2-nitrophenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

Guidance literature:: With N-Bromosuccinimide; In dichloromethane; at 0 ℃; for 12h;

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 1430728-82-7
N-(5-((4-(4,5-dihydro-1H-imidazol-2-yl)-2-nitrophenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

2: N-Bromosuccinimide / dichloromethane / 12 h

With potassium fluoride; N-Bromosuccinimide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1430728-82-7
N-(5-((4-(4,5-dihydro-1H-imidazol-2-yl)-2-nitrophenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2: 0.5 h / 0 - 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

5: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

6: N-Bromosuccinimide / dichloromethane / 12 h

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; iron; sodium carbonate; acetic acid; In methanol; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;