N-(5-((2-amino-4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

Base Information

Chemical Name:N-(5-((2-amino-4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide
CAS No.:1430728-83-8
Molecular Formula:C₂₃H₂₁F₂N₅O
Molecular Weight:421.449
Hs Code.:

Synonyms:N-(5-((2-amino-4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

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Chemical Property of N-(5-((2-amino-4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

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Technology Process of N-(5-((2-amino-4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

There total 10 articles about N-(5-((2-amino-4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1430728-82-7
N-(5-((4-(4,5-dihydro-1H-imidazol-2-yl)-2-nitrophenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

: 1430728-83-8
N-(5-((2-amino-4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

Guidance literature:: With ammonium chloride; zinc; In tetrahydrofuran; water; at 20 ℃; for 4h;

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 1430728-83-8
N-(5-((2-amino-4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

2: N-Bromosuccinimide / dichloromethane / 12 h

3: ammonium chloride; zinc / water; tetrahydrofuran / 4 h / 20 °C

With potassium fluoride; N-Bromosuccinimide; ammonium chloride; zinc; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1430728-83-8
N-(5-((2-amino-4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)amino)-2',4'-difluoro-[1,1'-biphenyl]-3-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2: 0.5 h / 0 - 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

5: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

6: N-Bromosuccinimide / dichloromethane / 12 h

7: ammonium chloride; zinc / water; tetrahydrofuran / 4 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; iron; sodium carbonate; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;